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Ground-Based Facilities for Studies in Gravitational Biology

Brungs, Sonja and Hemmersbach, Ruth (2015) Ground-Based Facilities for Studies in Gravitational Biology. The 6th China-Germany Workshop on Microgravity and Space Life Sciences, 26.-28. Sept. 2015, Hangzhou, China.

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Official URL: http://6thc-d.csp.escience.cn/dct/page/1

Abstract

Our group provides experimental platforms to simulate the conditions of microgravity on ground. Clinostats, a Random Positioning Machine and a Rotating Wall Vessel have been adapted to allow investigations employing a variety of different model organisms like larval fish, plants, algae, and unicellular organisms as well as adherent or suspended cells in culture. Different types of clinostats have been developed which meet a broad variety of scientific requirements in providing various kinds of experimental applications such as parallel operation of up to ten sample containments in a defined environment, direct microscopical observations of sample, their fixation during clinorotation, bioluminescence kinetic measurements within cell cultures and submersion of aquatic systems during rotation. Correspondingly, various centrifuge devices complete our experimental scenario, enabling hypergravity studies from cells to humans. Ground-based data should ideally be validated in the course of experiments carried out under real microgravity, which is regularly performed by us. Currently, our studies focus on the effects of simulated microgravity on macrophage signaling and stem cell development and differentiation. Simulation of microgravity as well as increased gravitational stimulation provide new insights how Biosystems cope with altered gravity conditions, showing changes in signaling pathways. Our results support the necessity of a ground-based facility program, which – at low costs in comparison to space flight – give scientists the opportunity to intensively prepare their space experiments and get sufficient and statistically reliable and relevant data.

Item URL in elib:https://elib.dlr.de/102952/
Document Type:Conference or Workshop Item (Speech)
Title:Ground-Based Facilities for Studies in Gravitational Biology
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Brungs, SonjaGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, GermanyUNSPECIFIED
Hemmersbach, RuthGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, GermanyUNSPECIFIED
Date:26 September 2015
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Page Range:p. 5
Status:Published
Keywords:Microgravity, Hypergravity, Clinostat, Centrifuge, Random Positioning Machine, Rotating Wall Vessel
Event Title:The 6th China-Germany Workshop on Microgravity and Space Life Sciences
Event Location:Hangzhou, China
Event Type:international Conference
Event Dates:26.-28. Sept. 2015
Organizer:Chinese Academy of Sciences, Chinese National Space Administration, German Aerospace Center (DLR), National Microgravity Laboratory
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Biomedical Research
Deposited By: Duwe, Helmut
Deposited On:11 Feb 2016 08:56
Last Modified:10 May 2016 23:44

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