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Local capillary supply in muscle is not determined by local oxidative capacity

Bosutti, A. and Egginton, S. and Barnouin, Y. and Ganse, B. and Rittweger, J. and Degens, H. (2015) Local capillary supply in muscle is not determined by local oxidative capacity. Journal of Experimental Biology, 218, pp. 3377-3380. The Company of Biologists. DOI: 10.1242/jeb.126664 ISSN 0022-0949

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Abstract

It is thought that the prime determinant of global muscle capillary density is the mean oxidative capacity. However, feedback control during maturational growth or adaptive remodelling of local muscle capillarisation is likely to be more complex than simply matching O2 supply and demand in response to integrated tissue function. We tested the hypothesis that the maximal oxygen consumption (MO2,max) supported by a capillary is relatively constant, and independent of the volume of tissue supplied (capillary domain). We demonstrate that local MO2,max assessed by succinate dehydrogenase histochemistry: (1) varied more than 100-fold between individual capillaries and (2) was positively correlated to capillary domain area in both human vastus lateralis (R=0.750, P<0.001) and soleus (R=0.697, P<0.001) muscles. This suggests that, in contrast to common assumptions, capillarisation is not primarily dictated by local oxidative capacity, but rather by factors such as fibre size, or consequences of differences in fibre size such as substrate delivery and metabolite removal.

Item URL in elib:https://elib.dlr.de/100849/
Document Type:Article
Title:Local capillary supply in muscle is not determined by local oxidative capacity
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Bosutti, A.Department of Clinical, Technological and Morphological Sciences, Division of Internal Medicine, University Triest, ItalienUNSPECIFIED
Egginton, S.School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UKUNSPECIFIED
Barnouin, Y.School of Healthcare Science, Manchester Metropolitan University, Manchester M1 5GD, UKUNSPECIFIED
Ganse, B.Division Space Physiology, Institute of Aerospace Medicine, German Aerospace Center, Cologne, bergita.ganse (at) dlr.deUNSPECIFIED
Rittweger, J.Institute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Degens, H.School of Healthcare Science, Manchester Metropolitan University, Manchester, UKUNSPECIFIED
Date:November 2015
Journal or Publication Title:Journal of Experimental Biology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:218
DOI :10.1242/jeb.126664
Page Range:pp. 3377-3380
Publisher:The Company of Biologists
ISSN:0022-0949
Status:Published
Keywords:Capillarisation; Capillary domains; Muscle; Succinate dehydrogenase
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:07 Jan 2016 17:00
Last Modified:10 May 2016 23:38

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