DLR-Logo -> http://www.dlr.de
DLR Portal Home | Impressum | Kontakt | English
Schriftgröße: [-] Text [+]

Anatomical sector analysis of load-bearing tibial bone structure during 90 days bed rest and 1- year recovery

Cervinka, Tomas und Rittweger, Jörn und Hyttinen, Jari und Felsenberg, Dieter und Sievänen, Harrir (2011) Anatomical sector analysis of load-bearing tibial bone structure during 90 days bed rest and 1- year recovery. Clinical Physiology and Functional Imaging, 31, Seiten 249-257.

PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader


The aim of this study was to investigate whether the bone response to long bed rest–related immobility and during subsequent recovery differed at anatomically different sectors of tibial epiphysis and diaphysis. For this study, peripheral quantitative tomographic (pQCT) scans obtained from a previous 90-day Long Term Bed Rest intervention were preprocessed with a new method based on statistical approach and re-analysed sector-wise. The pQCT was performed on 25 young healthy males twice before the bed rest, after the bed rest and after 1-year follow-up. All men underwent a strict bed rest intervention, and in addition, seven of them received pamidronate treatment and nine did flywheel exercises as countermeasures against disuse-related bone loss. Clearly, 3–9% sector-specific losses in trabecular density were observed at the tibial epiphysis on average. Similarly, cortical density decreased in a sectorspecific way being the largest at the anterior sector of tibial diaphysis. During recovery, the bed rest–induced bone losses were practically restored and no consistent sector-specific modulation was observed in any subgroup. It is concluded that the sector-specific analysis of bone cross-sections has potential to reveal skeletal responses to various interventions that cannot be inferred from the average analysis of the whole bone cross-section. This approach is considered also useful for evaluating the bone responses from the biomechanical point of view.

Titel:Anatomical sector analysis of load-bearing tibial bone structure during 90 days bed rest and 1- year recovery
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID
Cervinka, TomasTampere University of TechnologyNICHT SPEZIFIZIERT
Rittweger, Jörnjoern.rittweger@dlr.deNICHT SPEZIFIZIERT
Hyttinen, JariTampere University of TechnologyNICHT SPEZIFIZIERT
Felsenberg, DieterCharité Campus Benjamin FranklinNICHT SPEZIFIZIERT
Sievänen, HarrirUKK InstituteNICHT SPEZIFIZIERT
Erschienen in:Clinical Physiology and Functional Imaging
Referierte Publikation:Ja
In Open Access:Nein
In ISI Web of Science:Ja
Seitenbereich:Seiten 249-257
Stichwörter:bone loss; cortical bone; disuse; image preprocessing; trabecular bone
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Rittweger, Jörn
Hinterlegt am:27 Jun 2011 09:15
Letzte Änderung:12 Dez 2013 21:18

Nur für Mitarbeiter des Archivs: Kontrollseite des Eintrags

Hilfe & Kontakt
electronic library verwendet EPrints 3.3.12
Copyright © 2008-2017 Deutsches Zentrum für Luft- und Raumfahrt (DLR). Alle Rechte vorbehalten.