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Interindividual variabilities in cognitive performance degradation after alcohol consuption and sleep loss are related

Elmenhorst, Eva-Maria und Benderoth, S. und Vejvoda, M. und Wenzel, J. und Aeschbach, D. (2016) Interindividual variabilities in cognitive performance degradation after alcohol consuption and sleep loss are related. International Symposium on Somnolence, Vigilance and Safety, 2016-02-22 - 2016-02-23, Brüssel. (nicht veröffentlicht)

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Introduction The sleep inducing effects of alcohol as well as the increase in sleep propensity and sleepiness after sleep loss have been linked to the adenosinergic system in the brain. While the performance impairing effects of ethanol have partly been related to the inhibitory effects of cerebral adenosine, sleep loss has been found to increase adenosine receptor density. The interindividual variability of cognitive performance impairments after alcohol intake as well as after sleep loss is extensive. Thus, we examined in humans whether performance degradations resulting from sleep loss and alcohol consumption are related. Methods Performance in a 10-min Psychomotor Vigilance Task (PVT) was tested in 47 healthy volunteers (mean age 27 ± 5 (SD) years, 21 females) at 6 pm 1) after an 8 hour control night, 2) after alcohol consumption (aiming at a blood alcohol concentration (BAC) of 0.08%), and 3) after 35 hours of total sleep deprivation. After alcohol intake, 35 of the participants reached a BAC of more than 0.06% prior to the performance testing (mean BAC 0.074%, SD 0.009%, min. 0.063%, max. 0.095%) and were included in the analyses. Two recovery nights were scheduled between conditions. Results Performance impairments due to acute alcohol intake and due to 35 hours of sustained wakefulness were calculated as differences from performance under control conditions. The degree in performance degradation correlated highly between both conditions (i.e. 10% slowest reaction times: Pearson’s r=0.73, p<0.0001; standard deviation of reaction times: r=0.75, p<0.0001; mean reaction time: r=0.59, p=0.0002). Conclusions Participants whose PVT performance proved to be vulnerable to the effects of alcohol consumption were also vulnerable to sleep loss, whereas individuals who were resilient against the effects of alcohol were also less susceptible to the impact of sleep deprivation. These results suggest that the effects of alcohol and sleep deprivation on performance are mediated – at least in part – by a common pathway that may involve the adenosinergic system in the brain.

elib-URL des Eintrags:https://elib.dlr.de/108435/
Dokumentart:Konferenzbeitrag (Vortrag)
Titel:Interindividual variabilities in cognitive performance degradation after alcohol consuption and sleep loss are related
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Elmenhorst, Eva-Mariaeva-maria.elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705NICHT SPEZIFIZIERT
Benderoth, S.sibylle.benderoth (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Vejvoda, M.martin.vejvoda (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Wenzel, J.juergen.wenzel (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Aeschbach, D.daniel.aeschbach (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:2016
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:nicht veröffentlicht
Stichwörter:sleep deprivation, performance, PVT, inter-individual differences, ethanol, adenosine
Veranstaltungstitel:International Symposium on Somnolence, Vigilance and Safety
Veranstaltungsort:Brüssel
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:22 Februar 2016
Veranstaltungsende:23 Februar 2016
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Luftfahrt
HGF - Programmthema:Luftverkehrsmanagement und Flugbetrieb
DLR - Schwerpunkt:Luftfahrt
DLR - Forschungsgebiet:L AO - Air Traffic Management and Operation
DLR - Teilgebiet (Projekt, Vorhaben):L - Faktor Mensch und Sicherheit in der Luftfahrt (alt), V - keine Zuordnung
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Flugphysiologie
Hinterlegt von: Sender, Alina
Hinterlegt am:29 Nov 2016 12:01
Letzte Änderung:24 Apr 2024 20:13

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