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Artificial gravity as a partially effective musculoskeletal countermeasure

Rittweger, Jörn und Bareille, Marie-Pierre und Clément, G. und Linnarsson, Dag und Paloski, William und Wuyts, F.L. und Zange, Jochen und Angerer, Oliver (2013) Artificial gravity as a partially effective musculoskeletal countermeasure. HiS 2013, 2013-07-07 - 2013-07-12, Cologne.

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Kurzfassung

Physical de-conditioning is a well-known consequence of spaceflight and its ground based analog of experimental bed rest. Human centrifugation, also called artificial gravity (AG) has been proposed as a unique way to replace gravitational acceleration and to thus provide a therapeutic strategy against all known (and potentially un-known) side-effects of microgravity exposure. The European Space Agency therefore commissioned the BRAG-1 study in order to assess countermeasure efficacy of its short arm human centrifuge. Eleven healthy male subjects with a mean age of 34 (sd 7) years participated in a cross-over study designed to compare the effects of 5-days head-down tilt bed rest when done without countermeasures, or when subjects performed AG with 1 g at the center of mass for either 6 x 5 minutes or for 1 x 30 minutes per day (AG6x5 and AG1x30, respectively). The study was carried out at MEDES in Toulouse, France. Blood and urine samples were obtained, and jump and muscle strength tests were performed during baseline data collection (BDC), head down tilt (HDT) and recovery (REC). Bone formation responses were equivocal, with increases in bone alkaline phosphatase during HDT and REC (P < 0.001), but decreases in P1NP during REC (P = 0.013). None of the two depicted a time*AG interaction (P > 0.3). Urinary markers of bone resorption showed the expected increases for CTX (+25%, P < 0.001) and NTX (+25% P < 0.001), with a trend for an increase in NTX excretion by AG( P = 0.093). Excretion of DPD, a less specific resorption marker, suggested the contrary, namely a complete sparing (P = 0.014) of bed rest-induced bone resorption by AG1x30. Nitrogen balance became negative during HDT (P < 0.001). This effect was equalized by AG6x5 on day HDT 4 (P < 0.001). Neuromuscular performance tests yielded equivocal results for knee extensor and plantar flexor muscle strength, but clear-cut HDT-related decreases in vertical jump performance in terms of height, power and peak acceleration (P values between < 0.001 and 0.015). Of note, AG effectively maintained jump height and power (P = 0.039 and P = 0.034, respectively). Whilst the 5-day bed rest format was probably too short to pick up HDT effects in muscle strength and bone turn-over, it yielded characteristic changes in all other endpoints. AG6x5 was better tolerated thanAG1x30, but both AG modalities seem to have positively affected nitrogen balance and vertical jump performance.

elib-URL des Eintrags:https://elib.dlr.de/88125/
Dokumentart:Konferenzbeitrag (Vortrag)
Titel:Artificial gravity as a partially effective musculoskeletal countermeasure
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Rittweger, Jörnjoern.rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963NICHT SPEZIFIZIERT
Bareille, Marie-PierreFrench Institute for Space Medicine and Physiology (MEDES) Clinique Spatiale, Toulouse, FranceNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Clément, G.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Linnarsson, DagKarolinska Institutet, Dept. of Physiology and Pharmacology, Sect. of Environmental PhysiologyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Paloski, WilliamNASA JSC, HoustonNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Wuyts, F.L.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Zange, JochenNICHT SPEZIFIZIERTNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Angerer, OliverESA, ESTEC, HSF-USL Nordwijk The NetherlandsNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:2013
Referierte Publikation:Nein
Open Access:Nein
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:Artificial gravitiy; musculoskeletal; countermeasure
Veranstaltungstitel:HiS 2013
Veranstaltungsort:Cologne
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:7 Juli 2013
Veranstaltungsende:12 Juli 2013
Veranstalter :DLR
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:keine Zuordnung
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R - keine Zuordnung
DLR - Teilgebiet (Projekt, Vorhaben):R - keine Zuordnung
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Becker, Christine
Hinterlegt am:13 Feb 2014 09:16
Letzte Änderung:24 Apr 2024 19:54

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