A prototype platform for mapping cohort metadata with environmental data: the MetaMap³ project

Kurzfassung

Introduction: The environment plays an increasingly important role for human health and efficient linkage of epidemiological cohorts with environmental data is crucial to quantify human exposures. We aimed to ease the search for appropriate exposure data for subsequent epidemiological analyses by generating and enriching interoperable and machine-readable metadata for exemplar cohort and exposure data and by mapping these metadata so that they can be jointly queried and searched. Methods: Our use case for cohort metadata consisted of the two German prospective, population-based birth cohorts GINIplus and LISAplus which were conducted in four study regions across Germany and included up to seven examination rounds since 1995. As use cases for environmental data, we considered land cover classification available for a single time point (06/2015-09/2017 mean) and daily soil moisture index data for the entire study period. Since both factors influence air temperature, they are of specific interest when investigating the effects of temperature extremes on human health. We reviewed several standards, strategies and tools and developed an approach to align the heterogenous metadata to a common structure and format. Results: We identified spatial and temporal coverage as the main mapping criteria. For the environmental metadata and the epidemiological metadata that have a spatial component (study centers, recruitment districts) we converged to the international standard for geographic information ISO 19115 and to the eXtensible Markup Language (XML). Based on our conceptual work, we identified the catalog application GeoNetwork as the best tool for our application and set up a test instance on a local server for our use cases metadata. Discussion: We are currently populating the mapping platform with further metadata and testing the full functionality of the tool, especially the filtering and search options of the application to enable the intended mapping.