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Phages as tools in spaceflight virology research

Pavletić, Bruno (2023) Phages as tools in spaceflight virology research. 8th European Congress of Virology 2023, 2023-05-04 - 2023-05-07, Gdańsk, Poland.

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Kurzfassung

Human missions to space are among highest goals of multiple spaceflight agencies, due to their high impact on science and society [1]. Space travel highly differs from the Earth environment. It is characterized by microgravity, high radiation doses, small confined spaces, limited resources, artificial day/night cycles and regulated temperature/humidity inside space modules. Such conditions have a complex repertoire of negative effects on human health. For instance, herpesviruses reactivate in astronauts due to the reduced immune function[2]. Due to their suppressed immune systems, astronauts are more susceptible to infection. This points out the necessity to assess the virus infection risks in the spaceflight environment, as getting a disease during a mission would result in reduced performance or mission failure. However, testing the infectious viruses in space is unsafe, due to unavailability of high biosafety standards in crew modules. Additionally, the possibility of aerosol spread is higher in microgravity as the larger droplets don’t settle down. Therefore, it is of interest to test and identify the virus surrogates optimal for spaceflight, preferably noninfectious and simple for performing stability and detection assays. Phages fit perfectly as they have a history of use as safe virus surrogates, simple to grow and test. Additional benefit of phages in spaceflight is as tools to prevent or remove biofilms. Biofilms cause material fouling, and clogging of pipes. Phages have already been shown to be effective tools for biofilm decontamination [3]. [...]

elib-URL des Eintrags:https://elib.dlr.de/195350/
Dokumentart:Konferenzbeitrag (Poster)
Titel:Phages as tools in spaceflight virology research
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Pavletić, BrunoRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:Mai 2023
Referierte Publikation:Ja
Open Access:Nein
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:Human missions to space, human health, virus infection risks in the spaceflight environment, virus surrogates, phages
Veranstaltungstitel:8th European Congress of Virology 2023
Veranstaltungsort:Gdańsk, Poland
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:4 Mai 2023
Veranstaltungsende:7 Mai 2023
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Projekt ISS LIFE 2.0
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:07 Jun 2023 11:52
Letzte Änderung:24 Apr 2024 20:55

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