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Long-term human spaceflight and inflammaging: Does it promote aging?

Capri, Miriam und Conte, Maria und Ciurca, Erika und Pirazzini, Chiara und Garagnani, Paolo und Santoro, Aurelia und Longo, Federica und Salvioli, Stefano und Lau, Patrick und Moeller, Ralf und Jordan, Jens und Illig, Thomas und Villanueva, Maria-Moreno und Gruber, Markus und Bürkle, Alexander und Franceschi, Claudio und Rittweger, Jörn (2023) Long-term human spaceflight and inflammaging: Does it promote aging? Ageing Research Reviews, 87, Seite 101909. Elsevier. doi: 10.1016/j.arr.2023.101909. ISSN 1568-1637.

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Offizielle URL: https://dx.doi.org/10.1016/j.arr.2023.101909

Kurzfassung

Spaceflight and its associated stressors, such as microgravity, radiation exposure, confinement, circadian derailment and disruptive workloads represent an unprecedented type of exposome that is entirely novel from an evolutionary stand point. Within this perspective, we aimed to review the effects of prolonged spaceflight on immune-neuroendocrine systems, brain and brain-gut axis, cardiovascular system and musculoskeletal apparatus, highlighting in particular the similarities with an accelerated aging process. In particular, spaceflightinduced muscle atrophy/sarcopenia and bone loss, vascular and metabolic changes, hyper and hypo reaction of innate and adaptive immune system appear to be modifications shared with the aging process. Most of these modifications are mediated by molecular events that include oxidative and mitochondrial stress, autophagy, DNA damage repair and telomere length alteration, among others, which directly or indirectly converge on the activation of an inflammatory response. According to the inflammaging theory of aging, such an inflammatory response could be a driver of an acceleration of the normal, physiological rate of aging and it is likely that all the systemic modifications in turn lead to an increase of inflammaging in a sort of vicious cycle. The most updated countermeasures to fight these modifications will be also discussed in the light of their possible application not only for astronauts’ benefit, but also for older adults on the ground.

elib-URL des Eintrags:https://elib.dlr.de/194447/
Dokumentart:Zeitschriftenbeitrag
Titel:Long-term human spaceflight and inflammaging: Does it promote aging?
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iD
Capri, MiriamDepartment of Medical and Surgical Science, University of Bologna, Bologna, Italy and Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, Bologna, Italy
Conte, MariaDepartment of Medical and Surgical Science, University of Bologna, Bologna, Italy and Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, Bologna, Italy
Ciurca, ErikaDepartment of Medical and Surgical Science, University of Bologna, Bologna, Italy
Pirazzini, ChiaraDepartment of Medical and Surgical Science, University of Bologna, Bologna, Italy
Garagnani, PaoloDepartment of Medical and Surgical Science, University of Bologna, Bologna, Italy and Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, Bologna, Italy
Santoro, AureliaDepartment of Medical and Surgical Science, University of Bologna, Bologna, Italy and Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, Bologna, Italy
Longo, FedericaDepartment of Medical and Surgical Science, University of Bologna, Bologna, Italy
Salvioli, StefanoDepartment of Medical and Surgical Science, University of Bologna, Bologna, Italy and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
Lau, PatrickPatrick.Lau (at) dlr.dehttps://orcid.org/0000-0002-7290-5875
Moeller, RalfRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.; ralf.moeller (at) dlr.dehttps://orcid.org/0000-0002-2371-0676
Jordan, JensInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Lehrstuhl für Luft- und Raumfahrtmedizin, Universität zu Köln; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Illig, ThomasDepartment of Human Genetics, Hannover Medical School, Hannover, Germany
Villanueva, Maria-MorenoHuman Performance Research Centre, Department of Sport Science, University of Konstanz, Konstanz, Germany
Gruber, MarkusHuman Performance Research Centre, Department of Sport Science, University of Konstanz, Konstanz, Germany
Bürkle, AlexanderDepartment of Biology, University of Konstanz, Konstanz, Germany
Franceschi, ClaudioDepartment of Applied Mathematics of the Institute of ITMM, National Research Lobachevsky State University of Nizhny Novgorod, the Russian Federation
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Datum:12 März 2023
Erschienen in:Ageing Research Reviews
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:87
DOI:10.1016/j.arr.2023.101909
Seitenbereich:Seite 101909
Verlag:Elsevier
ISSN:1568-1637
Status:veröffentlicht
Stichwörter:Exposome, Human spaceflight, Aging, Inflammaging, NF- κB
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Projekt ISS LIFE 2.0
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Muskel- und Knochenstoffwechsel
Institut für Luft- und Raumfahrtmedizin > Leitungsbereich ME
Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:05 Apr 2023 09:25
Letzte Änderung:18 Apr 2023 13:11

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