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Unravelling the microbial fitness and the acquired co-resistances towards environmental extremes of vancomycin resistant enterococci

Arndt, F. und Siems, K. und Boschert, A.L. und Walker, S. und Moeller, R. und Lipski, A. (2022) Unravelling the microbial fitness and the acquired co-resistances towards environmental extremes of vancomycin resistant enterococci. VAAM, Annual Conference 2022 of the Association for General and Applied Microbiology, 2022-02-21 - 2022-02-23, Düsseldorf/Jülich, Germany (virtual).

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Kurzfassung

The COVID-19 pandemic displayed how vital international cooperation and preparedness are in a crisis with over 4 million deaths worldwide. Now is the opportunity to prevent future microbial pandemics and respond with awareness, knowledge and preparedness. Antimicrobial resistances (AMR) spread globally via international travel and supply chains and there is an essential need for detecting future pandemic threats like AMR. The WHO listed vancomycin-resistant enterococci (VRE) with high priority on the global priority list of antibiotic resistant bacteria. As a cause of endemic hospital outbreaks worldwide, VRE emerged as nosocomial pathogens which are life threatening for immunosuppressed patients. Weakened immune functions are also a health issue for astronauts exposed to various stressors on long-term space missions. Therefore, VRE can become a threat whether on Earth or in space. To prevent VRE infections and guarantee the health of the crew members it is important to understand the influence of microgravity on the development of antibiotic resistances. Hence, antibiotic resistances of clinical isolates of sensible, low-level and high-level vancomycin resistant enterococci were investigated after simulated microgravity. Therefore, the minimal inhibitory concentration (MIC) was determined before and after simulated microgravity by using clinorotation. Additionally, stress tests for characterization under extreme environmental conditions were performed. As a result, the majority of the VRE isolates showed no change in their resistance behavior after simulated microgravity. Furthermore, as one of the extreme environmental conditions, the isolates showed an increased tolerance to desiccation after simulated microgravity. The fact that the VRE resistance behavior was similar under simulated microgravity to the control (normal terrestrial 1 x g) stresses importance under both conditions and allows for similar containment and therapy strategies both, on Earth and in space. To estimate the risk of VRE and their role in an upcoming pandemic of drug resistant infections it is essential to investigate VRE fitness and narrow down methods against the arising challenge of antibiotic resistant bacteria. Moreover, analysis of multistress factors of VRE and research of co-resistance towards environmental extremes and space conditions will improve the understanding how to fight drug resistant bacteria and, therefore, minimize healthcare-associated infections worldwide.

elib-URL des Eintrags:https://elib.dlr.de/190678/
Dokumentart:Konferenzbeitrag (Poster)
Titel:Unravelling the microbial fitness and the acquired co-resistances towards environmental extremes of vancomycin resistant enterococci
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Arndt, F.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Siems, K.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; katharina.siems (at) dlr.dehttps://orcid.org/0000-0001-7349-0846NICHT SPEZIFIZIERT
Boschert, A.L.Institute for Medical Microbiology, Immunology and Hygiene, Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Walker, S.Institute for Medical Microbiology, Immunology and Hygiene, Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Moeller, R.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; ralf.moeller (at) dlr.dehttps://orcid.org/0000-0002-2371-0676NICHT SPEZIFIZIERT
Lipski, A.Institute for Nutritional and Food Sciences, University of Bonn, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:Februar 2022
Referierte Publikation:Ja
Open Access:Nein
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:microbial pandemics, Antimicrobial resistances (AMR)
Veranstaltungstitel:VAAM, Annual Conference 2022 of the Association for General and Applied Microbiology
Veranstaltungsort:Düsseldorf/Jülich, Germany (virtual)
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:21 Februar 2022
Veranstaltungsende:23 Februar 2022
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Projekt ISS LIFE 2.0
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:29 Nov 2022 09:55
Letzte Änderung:24 Apr 2024 20:51

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