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Assessment of the adaptability of non-fastidious pathogenic bacteria to the Martian environment.

Zaccaria, T. und De Jonge, M. und Netea, M. und Domínguez-Andrés, J. und Eleveld, M. und Beblo-Vranesevic, K. und Rettberg, P. (2021) Assessment of the adaptability of non-fastidious pathogenic bacteria to the Martian environment. EANA 2021, 2021-09-07 - 2021-09-10, Virtual Conference.

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Kurzfassung

Understanding the extent to which non-fastidious pathogenic bacteria can survive in extraterrestrial conditions will help to improve astronaut safety. Despite stringent decontamination protocols, terrestrial microorganisms were previously found to travel on the bodies of astronauts, on spaceships and equipment. This might enable the microorganisms to adapt, grow and evolve in the new environment. In this study, we assessed the adaptability of clinically relevant bacteria species, which are able to grow on carbon-containing compounds identified in carbonaceous meteorites (Klebsiella pneumoniae, Burkholderia cepacia, Serratia marcescens and Pseudomonas aeruginosa), to the simulated Martian environment. Previous work has shown that bacterial survival and growth under these conditions led to the modification of their cell envelope, thereby altering their pathogenic potential. We continued with this line of research and explored the survival of these bacterial species to a range of simulated Martian conditions i.e., desiccation, UVC (254 nm) and polychromatic UV (200 - 400 nm) irradiation, growth in the presence of perchlorates, growth on Martian simulant and exposure to Martian atmospheric composition and pressure. Preliminary results showed that growth was enhanced by the addition of Mars Global simulant (mimicking Martian regolith) to the incubation media. Furthermore, these initial results showed that only two of the strains, K. pneumoniae and S. marcescens are tolerant to desiccation, up to 16 days. The UVC irradiation experiments have shown that the bacteria with the highest degree of survival are P. aeruginosa and S. marcescens. Likewise, the same two strains have shown higher survival rates compared to K. pneumoniae and B. cepacia when exposed to polychromatic UV irradiation. To investigate the consequences of survival and growth under simulated Martian conditions, on virulence and immune recognition, a follow-up study will analyze the response of immune cells placed in contact with bacteria exposed to the Martian environment. In addition, gene expression of the adapted bacteria will be further studied. This collaborative study between the DLR (German Aerospace Center) and the Radboud UMC, in the Netherlands has provided a starting point to the investigation into the adaptability of pathogenic bacteria to Martian conditions. Further studies are required in order to improve our insight on the effects of virulence and immune recognition of the exposed pathogens. This could enable us to potentially anticipate the risks of infection and inflammation during space-travel and exploration.

elib-URL des Eintrags:https://elib.dlr.de/143861/
Dokumentart:Konferenzbeitrag (Poster)
Titel:Assessment of the adaptability of non-fastidious pathogenic bacteria to the Martian environment.
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Zaccaria, T.Radboud University, Nijmegen, Netherlands and Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
De Jonge, M.Section Pediatric Infectious Diseases, Laboratory of Medical Immunology Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands and Department of Internal Medicine, Radboud University Medical Center, Nijmegen, NL.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Netea, M.Radboud University Medical Center, Nijmegen, Netherlands and Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Domínguez-Andrés, J.Department of Internal Medicine and Radboud Center for Infectious Diseasesand Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Eleveld, M.Section Pediatric Infectious Diseases, Laboratory of Medical Immunology Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands and Department of Internal Medicine, Radboud University Medical Center, Nijmegen, NL.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Beblo-Vranesevic, K.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; kristina.beblo (at) dlr.dehttps://orcid.org/0000-0002-4834-7121NICHT SPEZIFIZIERT
Rettberg, P.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; petra.rettberg (at) dlr.dehttps://orcid.org/0000-0003-4439-2395NICHT SPEZIFIZIERT
Datum:September 2021
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:non-fastidious pathogenic bacteria, survival, Mars, Martian conditions, space-travel and exploration
Veranstaltungstitel:EANA 2021
Veranstaltungsort:Virtual Conference
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:7 September 2021
Veranstaltungsende:10 September 2021
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Projekt ISS LIFE 2.0
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:17 Sep 2021 08:39
Letzte Änderung:24 Apr 2024 20:43

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