Meringer, Markus und Cleaves, H. James (2019) Computational Exploration of the Chemical Space Surrounding the Molecules of Life. Science of Early Life Conference 2019, 2019-11-18 - 2019-11-20, Kloster Seeon, Germany.
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Offizielle URL: https://www.cup.lmu.de/oc/trapp/sel2019.html
Kurzfassung
How the transition of disorganized, inanimate matter to organized, living systems took place on our planet and might have occurred on other bodies of our solar system or elsewhere in the universe is one of the fundamental questions studied in the field of astrobiology. The only instance of life known so far is the terrestrial one, and all living organisms on Earth share many of the same biochemical foundations with respect to reproduction and metabolism. These biochemical foundations rely on a small pool of biomolecules, which represent a minute subset of plausible structural analogs, which themselves form only a very small fraction of all possible chemical compounds in chemical space. We believe that one key to understanding the origins of life is to study biomolecules in the context of their surrounding neighborhood in chemical space. Using unique software tools, so-called structure generators, we are able to exhaustively construct well defined subsets of chemical space. These virtual compound libraries are then computationally analyzed with respect to the physico-chemical properties of their constituents. In this talk some basic mathematical models and computational aspects of generating molecular structures are presented, results concerning the amino acid alphabet, nucleotide analogs and the core of intermediary metabolism are summarized, and perspectives of ongoing studies related to astrobiology exploration missions are outlined.
elib-URL des Eintrags: | https://elib.dlr.de/130400/ | ||||||||||||
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Dokumentart: | Konferenzbeitrag (Vortrag) | ||||||||||||
Titel: | Computational Exploration of the Chemical Space Surrounding the Molecules of Life | ||||||||||||
Autoren: |
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Datum: | 20 November 2019 | ||||||||||||
Referierte Publikation: | Nein | ||||||||||||
Open Access: | Ja | ||||||||||||
Gold Open Access: | Nein | ||||||||||||
In SCOPUS: | Nein | ||||||||||||
In ISI Web of Science: | Nein | ||||||||||||
Status: | veröffentlicht | ||||||||||||
Stichwörter: | chemical space, structure generation algorithms, virtual libraries, amino acids, nucleotide analogs, intermediary metabolism, origins of life, astrobiology | ||||||||||||
Veranstaltungstitel: | Science of Early Life Conference 2019 | ||||||||||||
Veranstaltungsort: | Kloster Seeon, Germany | ||||||||||||
Veranstaltungsart: | internationale Konferenz | ||||||||||||
Veranstaltungsbeginn: | 18 November 2019 | ||||||||||||
Veranstaltungsende: | 20 November 2019 | ||||||||||||
HGF - Forschungsbereich: | Luftfahrt, Raumfahrt und Verkehr | ||||||||||||
HGF - Programm: | Raumfahrt | ||||||||||||
HGF - Programmthema: | Erforschung des Weltraums | ||||||||||||
DLR - Schwerpunkt: | Raumfahrt | ||||||||||||
DLR - Forschungsgebiet: | R EW - Erforschung des Weltraums | ||||||||||||
DLR - Teilgebiet (Projekt, Vorhaben): | R - Explorationsstudien (alt) | ||||||||||||
Standort: | Oberpfaffenhofen | ||||||||||||
Institute & Einrichtungen: | Institut für Methodik der Fernerkundung > Atmosphärenprozessoren | ||||||||||||
Hinterlegt von: | Meringer, Dr.rer.nat. Markus | ||||||||||||
Hinterlegt am: | 25 Nov 2019 13:08 | ||||||||||||
Letzte Änderung: | 24 Apr 2024 20:33 |
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