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A combination of whey protein and potassium bicarbonate supplements during head-down-tilt bed rest: Presentation of a multidisciplinary randomized controlled trial (MEP study)

Bühlmeier, Judith and Mulder, Edwin and Noppe, Alexandra and Frings-Meuthen, Petra and Angerer, Oliver and Rudwill, Floriane and Biolo, Gianni and Smith, Scott M. and Blanc, Stéphane and Heer, Martina (2014) A combination of whey protein and potassium bicarbonate supplements during head-down-tilt bed rest: Presentation of a multidisciplinary randomized controlled trial (MEP study). Acta Astronautica. ISSN 0094-5765.

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Abstract

Inactivity, as it appears during space flight and in bed rest, induces reduction of lean body and bone mass, glucose intolerance, and weakening of the cardiovascular system. Increased protein intake, whey protein in particular, has been proposed to counteract some of these effects, but has also been associated with negative effects on bone, likely caused by a correspondingly high ratio of acid to alkali precursors in the diet. The main hypothesis of the presented cross-over study (MEP study) was that supplementing high protein intake (1.2 g/kg body weight/d plus 0.6 g/kg body weight/d whey protein) with alkaline salts (90 mmol potassium bicarbonate/d) will maintain lean body mass during bed rest without increasing bone resorption. A 21-day head-down-tilt bed rest study was performed to examine several physiological systems in a multidisciplinary approach. Ten healthy men (age: 31±6 years; body weight: 76.5±5.6 kg) were randomly assigned to the dietary countermeasure or isocaloric control first, one test subject randomized to the dietary countermeasure first dropped out after the first campaign.

Document Type:Article
Title:A combination of whey protein and potassium bicarbonate supplements during head-down-tilt bed rest: Presentation of a multidisciplinary randomized controlled trial (MEP study)
Authors:
AuthorsInstitution or Email of Authors
Bühlmeier, JudithUniversity of Bonn, Germany
Mulder, EdwinGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, Germany
Noppe, AlexandraGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany
Frings-Meuthen, PetraGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, Germany
Angerer, OliverHE Space for ESA, Nordwijk The Netherlands
Rudwill, FlorianeUniversité de Strasbourg, France
Biolo, GianniUniversity of Trieste, Italy
Smith, Scott M.NASA, Johnson Space Center, Houston, USA
Blanc, StéphaneUniversité de Strasbourg, CNRS, Institut Pluridisciplinaire Hubert Curien, France
Heer, MartinaProfil Neuss GmbH, Neuss, Germany
Date:2014
Journal or Publication Title:Acta Astronautica
Refereed publication:Yes
In Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
ISSN:0094-5765
Status:Accepted
Keywords:Immobilization, Space flight analog, Nutrition, Countermeasure, Standardization, Physical activity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:other
DLR - Research area:Raumfahrt
DLR - Program:R - no assignement
DLR - Research theme (Project):R -- no assignement
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: Alexandra Noppe
Deposited On:10 Feb 2014 09:15
Last Modified:10 Feb 2014 09:15

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