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Determinants of Skeletal Muscle Hypertrophy and the Attenuated Hypertrophic Response at Old Age

Degens, Hans (2012) Determinants of Skeletal Muscle Hypertrophy and the Attenuated Hypertrophic Response at Old Age. Journal of Sports Medicine & Doping Studies, pp. 2-9. OMICS Publishing Group. DOI: 10.4172/2161-0673.S1-003.

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Official URL: http://www.omicsonline.org/2161-0673/pdfdownload.php?download=2161-0673-S1-003.pdf

Abstract

In 2012 we will again see the impressive achievements of many athletes during the London Olympic Games. In particular for weightlifters success is dependent on the power- and force-generating capacity of their muscles, which in turn are strongly determined by muscle mass. Many athletes and bodybuilders therefore train intensively to develop as much muscle hypertrophy as possible. Unlimited hypertrophy, however, is impossible. Limitations may be imposed by the peak forces that the tendons, bones and joints can cope with, but also by factors within the muscles themselves. For instance, an increase in pennation angle, which accompanies hypertrophy, beyond 450 would result in a reduction in muscle strength even if muscle mass continuous to increase. There also is a trade-off between metabolism and diffusion, where highly oxidative fibers require shorter diffusion distances, and hence smaller fibers, for adequate oxygen supply to the mitochondria, than glycolytic fibers. A similar situation applies to the myonuclei where transcripts are distributed over the cell mainly by diffusion and unbridled hypertrophy would, at least in theory, cause serious problems with fiber maintenance. Despite these limiting factors muscles in bodybuilders can be as much as 74% larger than in the normal population. Elderly people have a lower muscle mass that may cause problems with daily life activities and an increase in muscle strength would improve their quality of life. There are indications, however, that the maximal attainable hypertrophy is significantly reduced in the elderly. Here it is suggested that while individual fibers in the elderly may hypertrophy to a similar extent as their younger counterparts, the age-related loss of muscle fibers is an additional limiting factor of the whole muscle hypertrophy at old age.

Document Type:Article
Title:Determinants of Skeletal Muscle Hypertrophy and the Attenuated Hypertrophic Response at Old Age
Authors:
AuthorsInstitution or Email of Authors
Degens, Hansh.degens@mmu.ac.uk
Date:27 February 2012
Journal or Publication Title:Journal of Sports Medicine & Doping Studies
DOI:10.4172/2161-0673.S1-003
Page Range:pp. 2-9
Editors:
EditorsEmail
Bunn, Jennifer A.UNSPECIFIED
Publisher:OMICS Publishing Group
Status:Published
Keywords:Myonuclear domain; Microcirculation; Specific tension; Anatomy; Diffusion
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Christine Becker
Deposited On:14 Sep 2012 11:59
Last Modified:12 Dec 2013 21:45

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