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Determinants of Skeletal Muscle Hypertrophy and the Attenuated Hypertrophic Response at Old Age

Degens, Hans (2012) Determinants of Skeletal Muscle Hypertrophy and the Attenuated Hypertrophic Response at Old Age. Journal of Sports Medicine & Doping Studies, Seiten 2-9. OMICS Publishing Group. DOI: 10.4172/2161-0673.S1-003

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In 2012 we will again see the impressive achievements of many athletes during the London Olympic Games. In particular for weightlifters success is dependent on the power- and force-generating capacity of their muscles, which in turn are strongly determined by muscle mass. Many athletes and bodybuilders therefore train intensively to develop as much muscle hypertrophy as possible. Unlimited hypertrophy, however, is impossible. Limitations may be imposed by the peak forces that the tendons, bones and joints can cope with, but also by factors within the muscles themselves. For instance, an increase in pennation angle, which accompanies hypertrophy, beyond 450 would result in a reduction in muscle strength even if muscle mass continuous to increase. There also is a trade-off between metabolism and diffusion, where highly oxidative fibers require shorter diffusion distances, and hence smaller fibers, for adequate oxygen supply to the mitochondria, than glycolytic fibers. A similar situation applies to the myonuclei where transcripts are distributed over the cell mainly by diffusion and unbridled hypertrophy would, at least in theory, cause serious problems with fiber maintenance. Despite these limiting factors muscles in bodybuilders can be as much as 74% larger than in the normal population. Elderly people have a lower muscle mass that may cause problems with daily life activities and an increase in muscle strength would improve their quality of life. There are indications, however, that the maximal attainable hypertrophy is significantly reduced in the elderly. Here it is suggested that while individual fibers in the elderly may hypertrophy to a similar extent as their younger counterparts, the age-related loss of muscle fibers is an additional limiting factor of the whole muscle hypertrophy at old age.

Titel:Determinants of Skeletal Muscle Hypertrophy and the Attenuated Hypertrophic Response at Old Age
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iD
Degens, Hansh.degens@mmu.ac.ukNICHT SPEZIFIZIERT
Datum:27 Februar 2012
Erschienen in:Journal of Sports Medicine & Doping Studies
In Open Access:Nein
In ISI Web of Science:Nein
DOI :10.4172/2161-0673.S1-003
Seitenbereich:Seiten 2-9
HerausgeberInstitution und/oder E-Mail-Adresse der Herausgeber
Verlag:OMICS Publishing Group
Stichwörter:Myonuclear domain; Microcirculation; Specific tension; Anatomy; Diffusion
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Becker, Christine
Hinterlegt am:14 Sep 2012 11:59
Letzte Änderung:12 Dez 2013 21:45

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