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EFFECTS OF ALFACALCIDOL ON THE CONTRACTILE PROPERTIES OF THE GASTROCNEMIUS MEDIALIS MUSCLE IN ADULT AND OLD RATS

Testerink, Janwillem und Degens, Hans und Rittweger, Jörn und A, Shiraishi und Richard T, Jaspers und de Haan, Arnold (2011) EFFECTS OF ALFACALCIDOL ON THE CONTRACTILE PROPERTIES OF THE GASTROCNEMIUS MEDIALIS MUSCLE IN ADULT AND OLD RATS. Journal of Physiology and Pharmacology, 62 (1), Seiten 111-118.

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Kurzfassung

Vitamin D deficiency is associated with muscle weakness. It is unknown, however, how supra-physiological levels of vitamin D affect skeletal muscle. To investigate the effects of increased serum vitamin D (1,25 (OH)2D3 or 1,25D) levels on the contractile properties of the medial gastrocnemius muscle, adult and old female Fischer344 x Brown Norway F1 rats were orally treated with vehicle or the vitamin D analogue alfacalcidol for 1 or 6 weeks. Alfacalcidol treatment resulted in elevated 1,25D serum levels. This was accompanied by hypercalcaemia and a reduction in body mass, the latter largely attributable to a reduced food intake. However, kidney function, as reflected by normal creatinine serum levels, as well as heart mass were unaffected. The 17% reduction in maximal isometric force and power was explicable by a similar loss of muscle mass. The force-frequency relationship of the 6-week-treated old rats was shifted to the left, but neither the shape of the force-velocity relationship nor the fatigability of the muscle were altered. Supraphysiological doses of vitamin D were accompanied by significant reductions in body and muscle mass, but not by an improvement in muscle functioning. Weight loss was largely due to a reduced food intake, while the left shift in the force-frequency relation may be due to increased 1,25D levels.

Dokumentart:Zeitschriftenbeitrag
Titel:EFFECTS OF ALFACALCIDOL ON THE CONTRACTILE PROPERTIES OF THE GASTROCNEMIUS MEDIALIS MUSCLE IN ADULT AND OLD RATS
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID
Testerink, JanwillemFree University AmsterdamNICHT SPEZIFIZIERT
Degens, HansManchester Metropolitan UniversityNICHT SPEZIFIZIERT
Rittweger, Jörnjoern.rittweger@dlr.deNICHT SPEZIFIZIERT
A, ShiraishiChugai PharmaceuticalsNICHT SPEZIFIZIERT
Richard T, JaspersFree University AmsterdamNICHT SPEZIFIZIERT
de Haan, ArnoldFree University AmsterdamNICHT SPEZIFIZIERT
Datum:2011
Erschienen in:Journal of Physiology and Pharmacology
Referierte Publikation:Ja
In Open Access:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:62
Seitenbereich:Seiten 111-118
Status:veröffentlicht
Stichwörter:alfacalcidol, fatigue, muscle contractile properties, skeletal muscle, vitamin D
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Rittweger, Jörn
Hinterlegt am:16 Jun 2011 12:36
Letzte Änderung:12 Dez 2013 21:16

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