elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Contact | Deutsch
Fontsize: [-] Text [+]

EFFECTS OF ALFACALCIDOL ON THE CONTRACTILE PROPERTIES OF THE GASTROCNEMIUS MEDIALIS MUSCLE IN ADULT AND OLD RATS

Testerink, Janwillem and Degens, Hans and Rittweger, Jörn and A, Shiraishi and Richard T, Jaspers and de Haan, Arnold (2011) EFFECTS OF ALFACALCIDOL ON THE CONTRACTILE PROPERTIES OF THE GASTROCNEMIUS MEDIALIS MUSCLE IN ADULT AND OLD RATS. Journal of Physiology and Pharmacology, 62 (1), pp. 111-118.

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
284kB

Abstract

Vitamin D deficiency is associated with muscle weakness. It is unknown, however, how supra-physiological levels of vitamin D affect skeletal muscle. To investigate the effects of increased serum vitamin D (1,25 (OH)2D3 or 1,25D) levels on the contractile properties of the medial gastrocnemius muscle, adult and old female Fischer344 x Brown Norway F1 rats were orally treated with vehicle or the vitamin D analogue alfacalcidol for 1 or 6 weeks. Alfacalcidol treatment resulted in elevated 1,25D serum levels. This was accompanied by hypercalcaemia and a reduction in body mass, the latter largely attributable to a reduced food intake. However, kidney function, as reflected by normal creatinine serum levels, as well as heart mass were unaffected. The 17% reduction in maximal isometric force and power was explicable by a similar loss of muscle mass. The force-frequency relationship of the 6-week-treated old rats was shifted to the left, but neither the shape of the force-velocity relationship nor the fatigability of the muscle were altered. Supraphysiological doses of vitamin D were accompanied by significant reductions in body and muscle mass, but not by an improvement in muscle functioning. Weight loss was largely due to a reduced food intake, while the left shift in the force-frequency relation may be due to increased 1,25D levels.

Document Type:Article
Title:EFFECTS OF ALFACALCIDOL ON THE CONTRACTILE PROPERTIES OF THE GASTROCNEMIUS MEDIALIS MUSCLE IN ADULT AND OLD RATS
Authors:
AuthorsInstitution or Email of Authors
Testerink, JanwillemFree University Amsterdam
Degens, HansManchester Metropolitan University
Rittweger, Jörnjoern.rittweger@dlr.de
A, ShiraishiChugai Pharmaceuticals
Richard T, JaspersFree University Amsterdam
de Haan, ArnoldFree University Amsterdam
Date:2011
Journal or Publication Title:Journal of Physiology and Pharmacology
Refereed publication:Yes
In Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:62
Page Range:pp. 111-118
Status:Published
Keywords:alfacalcidol, fatigue, muscle contractile properties, skeletal muscle, vitamin D
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Jörn Rittweger
Deposited On:16 Jun 2011 12:36
Last Modified:12 Dec 2013 21:16

Repository Staff Only: item control page

Browse
Search
Help & Contact
Informationen
electronic library is running on EPrints 3.3.12
Copyright © 2008-2012 German Aerospace Center (DLR). All rights reserved.