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Effects of smoking on tibial and radial bone mass and strength may diminish with age

Wüst, Rob und Winwood, Keith und Wilks, Désirée C. und Morse, Christopher I und Degens, Hans und Rittweger, Jörn (2010) Effects of smoking on tibial and radial bone mass and strength may diminish with age. Journal of Clinical Endocrinology and Metabolism, 95 (6), Seiten 2763-2771.

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Purpose: The purpose of the study was to assess the effect of cigarette smoking on indicators of bone strength across a wide age range, controlling for physical activity and neuromuscular performance. Methods:Weconducted a cross-sectional study with 41 smokers (mean age ±SD, 41.0±16.1 yr) and 53 nonsmokers (47.5 ± 18.2 yr) of both sexes. Bone strength indicators (BSI) were assessed in the lower leg and forearm by peripheral quantitative computed tomography along with physical activity, muscle cross-sectional area, and maximal voluntary muscle force. Results: Physical activity level and muscle cross-sectional area of the leg and arm were similar in smokers and nonsmokers. Although trabecular volumetric bone mineral density and epiphyseal bone mineral content, both indicators of BSI, decreased with age in the nonsmokers’ tibia (P < 0.001), this was not observed in the smokers (interaction age X smoking: P < 0.014 and P < 0.032 for density and content, respectively). Regression coefficients were nonsignificant in nonsmokers, whereas coefficients in smokers were -1.24 mg/cm * yr [95% confidence interval (CI) = -2.16– 0.33; P < 0.01] for content and -1.20 mg/cm3 * yr (95% CI = -1.76–0.62; P < 0.001) for trabecular density. The BSI values in the smokers were independent of their smoking history (r2 0.000– 0.021), and no effects of sex were observed in the smoking-related differences in BSI. Conclusions: Smoking compromises bone strength by diaphyseal marrow cavity expansion and epiphyseal trabecular bone content reductions. These effects seem to wane with age. The causes of the attenuated effect of smoking on bone at old age remain enigmatic but might be linked to an interaction between the smoke-related factors and senescence processes affecting bone.

Dokumentart:Zeitschriftenbeitrag
Titel:Effects of smoking on tibial and radial bone mass and strength may diminish with age
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Wüst, RobUniversity of Leeds
Winwood, KeithManchester Metropolitan University
Wilks, Désirée C.Manchester Metropolitan University
Morse, Christopher IManchester Metropolitan University
Degens, HansManchester Metropolitan University
Rittweger, JörnManchester Metropolityn University
Datum:2010
Erschienen in:Journal of Clinical Endocrinology and Metabolism
Referierte Publikation:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:95
Seitenbereich:Seiten 2763-2771
Status:veröffentlicht
Stichwörter:Osteoporosis, life style, aging
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Jörn Rittweger
Hinterlegt am:16 Jul 2010 09:34
Letzte Änderung:12 Dez 2013 20:58

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