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Structural analysis of the human tibia by tomographic (pQCT) serial scans

Capozza, Ricardo and Feldman, Sara and Mortarino, Pablo and Reina, Paola and Schiessl, Hans and Rittweger, Jörn and Ferretti, Jose Luis and Cointry, Gustavo (2010) Structural analysis of the human tibia by tomographic (pQCT) serial scans. Journal of Anatomy, 216, pp. 470-481.

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Abstract

This study analyses the evaluation of tomographic indicators of tibia structure, assuming that the usual loading pattern shifts from uniaxial compression close to the heel to a combined compression, torsion and bending scheme towards the knee. To this end, pQCT scans were obtained at 5% intervals of the tibia length (S5–S95 sites from heel to knee) in healthy men and women (10 ⁄ 10) aged 20–40 years. Indicators of bone mass [cortical area, cortical ⁄ total bone mineral content (BMC)], diaphyseal design (peri ⁄ endosteal perimeters, cortical thickness, circularity, bending ⁄ torsion moments of inertia – CSMIs), and material quality [(cortical vBMD (bone mineral density)] were determined. The longitudinal patterns of variation of these measures were similar between genders, but male values were always higher except for cortical vBMD. Expression of BMC data as percentages of the minimal values obtained along the bone eliminated those differences. The correlative variations in cortical area, BMC and thickness, periosteal perimeter and CSMIs along the bone showed that cortical bone mass was predominantly associated with cortical thickness toward the mid-diaphysis, and with bone diameter and CSMIs moving more proximally. Positive relationships between CSMIs (y) and total BMC (x) showed men’s values shifting to the upper-right region of the graph and women’s values shifting to the lower-left region. Total BMC decayed about 33% from S5 to S15 (where minimum total BMC and CSMI values and variances and maximum circularity were observed) and increased until S45, reaching the original S5 value at S40. The observed gender-related differences reflected the natural allometric relationships. However, the data also suggested that men distribute their available cortical mass more efficiently than women. The minimum amount and variance of mass indicators and CSMIs, and the largest circularity observed at S15 reflected the assumed adaptation to compression pattern at that level. The increase in CSMIs (successively for torsion, A–P bending, and lateral bending), the decrease in circularity values and the changes in cortical thickness and periosteal perimeter toward the knee described the progressive adaptation to increasing torsion and bending stresses. In agreement with the biomechanical background, the described relationships: (i) identify the sites at which some changes in tibial stresses and diaphyseal structure take place, possibly associated with fracture incidence; (ii) allow prediction of mass indicators at any site from single determinations; (iii) establish the proportionality between the total bone mass at regions with highly predominant trabecular and cortical bone of the same individual, suitable for a specific evaluation of changes in trabecular mass; and (iv) evaluate the ability of bone tissue to self-distribute the available cortical bone according to specific stress patterns, avoiding many anthropometric and gender-derived influences.

Document Type:Article
Title:Structural analysis of the human tibia by tomographic (pQCT) serial scans
Authors:
AuthorsInstitution or Email of Authors
Capozza, Ricardorcapozza@gmail.com
Feldman, Sarasaryfeldman@yahoo.com.ar
Mortarino, Pablopablo2086@hotmail.com
Reina, Paolapaoreina@gmail.com
Schiessl, HansNovotec Medical
Rittweger, Jörnjoern.rittweger@dlr.de
Ferretti, Jose Luisjlferretti@arnet.com.ar
Cointry, Gustavogcointry@gmail.com
Date:2010
Journal or Publication Title:Journal of Anatomy
Refereed publication:Yes
In Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:216
Page Range:pp. 470-481
Status:Published
Keywords:bone biomechanics; bone structure; human tibia; peripheral quantitative computed tomography; tibia anatomy; tibia biomechanics; tibia structure
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Jörn Rittweger
Deposited On:16 Jul 2010 10:04
Last Modified:12 Dec 2013 20:58

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