elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Impressum | Datenschutz | Kontakt | English
Schriftgröße: [-] Text [+]

The importance of timing potassium bicarbonate supplementation to affect acid-base balance

Boehme, G. und Frings- Meuthen, P. und Buehlmeier, J. und Heer , M. (2009) The importance of timing potassium bicarbonate supplementation to affect acid-base balance. In: 7th International Symposium on Nutritional Aspects of Osteoporosis (ISNAO 2009). 7th International Symposium on Nutritional Aspects of Osteoporosis (ISNAO 2009), 2009-05-06 - 2009-05-09, Lausanne.

Dieses Archiv kann nicht den Volltext zur Verfügung stellen.

Kurzfassung

In dealing with the negative consequences of a low-grade-metabolic acidosis, induced partially by the western industrialized world’s nutrient composition, alkaline salts such as potassium bicarbonate (KHCO3) have shown to serve as an effective countermeasure. We have recently shown that high sodium chloride (NaCl) intake also induces a low-grade metabolic acidosis. However, timing of the alkaline salt’s application relative to a meal might lead to different responses. Therefore, the main aim of the present study was to determine the ideal time for the intake of KHCO3 relative to a sodium chloride abundant meal. 10 subjects (6 male, 4 female) completed 4 identically scheduled days of the experiment, with 1 day for the control experiment (no supplementation) and 3 days for the different interventions (supplementation of 45mmol KHCO3 before, with or after lunch, respectively). Meals and bloodgas analyses (measured parameters: pH, HCO3-, base excess (BE)) were appointed at definite times. Additionally, a questionnaire monitored any side effects of the supplementation, possibly gastrointestinal disturbances (e.g. flatulence, nausea, diarrhea). Supplementing KHCO3 results in a more alkaline status within the normal range compared to the control (control/different times of supplementation: HCO3- 24mmol/L/ 26mmol/L (p=0.02); BE 0mmol/L/ 1mmol/L (p=0.002)) (before meal: HCO3- /BE: p=0.02/p=0.002; with the meal: p=0.02/p=0.002; after meal: p=0.003/p<=0.001). In this context pH showed significant effects in only two different times of supplementation (during meal (p=0.007), after lunch (p<=0.001)). Except for pH (p=0.01, originating from the supplementation after lunch) timing of the supplements did not lead to different results (HCO3-: p=0.24; BE (p=0.24). Regarding the side effects, subjects were most comfortable in the supplementation with the meal. With the present study, the positive effects of a KHCO3´s administration on the acid-base balance in combination to a sodium chloride abundant meal were confirmed. In aiming to advise an ideal time of KHCO3`s- intake with the focus on all three main descriptive parameters the results make no allowance for setting an advisable time of intake. When taking into account the side effects supplementation of KHCO3 with the meal is highly appreciated.

elib-URL des Eintrags:https://elib.dlr.de/60104/
Dokumentart:Konferenzbeitrag (Poster)
Titel:The importance of timing potassium bicarbonate supplementation to affect acid-base balance
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Boehme, G.NICHT SPEZIFIZIERTNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Frings- Meuthen, P. NICHT SPEZIFIZIERTNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Buehlmeier, J. NICHT SPEZIFIZIERTNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Heer , M. NICHT SPEZIFIZIERTNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:Mai 2009
Erschienen in:7th International Symposium on Nutritional Aspects of Osteoporosis (ISNAO 2009)
Open Access:Nein
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:alkaline salts, acid- base- balance, KHCO3
Veranstaltungstitel:7th International Symposium on Nutritional Aspects of Osteoporosis (ISNAO 2009)
Veranstaltungsort:Lausanne
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:6 Mai 2009
Veranstaltungsende:9 Mai 2009
HGF - Forschungsbereich:keine Zuordnung
HGF - Programm:keine Zuordnung
HGF - Programmthema:keine Zuordnung
DLR - Schwerpunkt:keine Zuordnung
DLR - Forschungsgebiet:keine Zuordnung
DLR - Teilgebiet (Projekt, Vorhaben):keine Zuordnung
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Böhme, Gisela
Hinterlegt am:05 Nov 2009 13:20
Letzte Änderung:24 Apr 2024 19:24

Nur für Mitarbeiter des Archivs: Kontrollseite des Eintrags

Blättern
Suchen
Hilfe & Kontakt
Informationen
electronic library verwendet EPrints 3.3.12
Gestaltung Webseite und Datenbank: Copyright © Deutsches Zentrum für Luft- und Raumfahrt (DLR). Alle Rechte vorbehalten.