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Roles of the Major, Small, Acid-Soluble Spore Proteins and Spore-Specific and Universal DNA Repair Mechanisms in Resistance of Bacillus subtilis Spores to Ionizing Radiation from X Rays and High-Energy Charged-Particle Bombardment

Moeller, Ralf und Setlow, Peter und Horneck, Gerda und Berger, Thomas und Reitz, Günther und Rettberg, Petra und Doherty, Aidan J. und Okayasu, Ryuichi und Nicholson, Wayne L. (2008) Roles of the Major, Small, Acid-Soluble Spore Proteins and Spore-Specific and Universal DNA Repair Mechanisms in Resistance of Bacillus subtilis Spores to Ionizing Radiation from X Rays and High-Energy Charged-Particle Bombardment. JOURNAL OF BACTERIOLOGY, 190 (3), Seiten 1134-1140. American Society for Microbiology. DOI: doi:10.1128/JB.01644-07.

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Kurzfassung

The role of DNA repair by nonhomologous end joining (NHEJ), homologous recombination, spore photoproduct lyase, and DNA polymerase I and genome protection via α/β-type small, acid-soluble spore proteins (SASP) in Bacillus subtilis spore resistance to accelerated heavy ions (high-energy charged [HZE] particles) and X rays has been studied. Spores deficient in NHEJ and α/β-type SASP were significantly more sensitive to HZE particle bombardment and X-ray irradiation than were the recA, polA, and splB mutant and wild-type spores, indicating that NHEJ provides an efficient DNA double-strand break repair pathway during spore germination and that the loss of the α/β-type SASP leads to a significant radiosensitivity to ionizing radiation, suggesting the essential function of these spore proteins as protectants of spore DNA against ionizing radiation.

Dokumentart:Zeitschriftenbeitrag
Titel:Roles of the Major, Small, Acid-Soluble Spore Proteins and Spore-Specific and Universal DNA Repair Mechanisms in Resistance of Bacillus subtilis Spores to Ionizing Radiation from X Rays and High-Energy Charged-Particle Bombardment
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Moeller, RalfNICHT SPEZIFIZIERT
Setlow, PeterDepartment of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut
Horneck, GerdaNICHT SPEZIFIZIERT
Berger, ThomasNICHT SPEZIFIZIERT
Reitz, GüntherNICHT SPEZIFIZIERT
Rettberg, PetraNICHT SPEZIFIZIERT
Doherty, Aidan J.Genome Damage and Stability Centre, University of Sussex, Brighton BN1, United Kingdom
Okayasu, RyuichiInternational Space Radiation Laboratory, National Institute of Radiological Sciences, Chiba-shi, Japan
Nicholson, Wayne L.University of Florida, Department of Microbiology and Cell Science, Space Life Sciences Laboratory, Kennedy Space Center, Florida
Datum:2008
Erschienen in:JOURNAL OF BACTERIOLOGY
Referierte Publikation:Ja
In ISI Web of Science:Ja
Band:190
DOI :doi:10.1128/JB.01644-07
Seitenbereich:Seiten 1134-1140
Verlag:American Society for Microbiology
Status:veröffentlicht
Stichwörter:Bacillus subtilis, HZE, X-Rays, DNA repair
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Strahlenbiologie (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kerstin Kopp
Hinterlegt am:19 Jun 2008
Letzte Änderung:27 Apr 2009 14:58

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