Moeller, Ralf and Setlow, Peter and Horneck, Gerda and Berger, Thomas and Reitz, Günther and Rettberg, Petra and Doherty, Aidan J. and Okayasu, Ryuichi and Nicholson, Wayne L. (2008) Roles of the Major, Small, Acid-Soluble Spore Proteins and Spore-Specific and Universal DNA Repair Mechanisms in Resistance of Bacillus subtilis Spores to Ionizing Radiation from X Rays and High-Energy Charged-Particle Bombardment. JOURNAL OF BACTERIOLOGY, 190 (3), pp. 1134-1140. American Society for Microbiology. DOI: doi:10.1128/JB.01644-07.
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The role of DNA repair by nonhomologous end joining (NHEJ), homologous recombination, spore photoproduct lyase, and DNA polymerase I and genome protection via α/β-type small, acid-soluble spore proteins (SASP) in Bacillus subtilis spore resistance to accelerated heavy ions (high-energy charged [HZE] particles) and X rays has been studied. Spores deficient in NHEJ and α/β-type SASP were significantly more sensitive to HZE particle bombardment and X-ray irradiation than were the recA, polA, and splB mutant and wild-type spores, indicating that NHEJ provides an efficient DNA double-strand break repair pathway during spore germination and that the loss of the α/β-type SASP leads to a significant radiosensitivity to ionizing radiation, suggesting the essential function of these spore proteins as protectants of spore DNA against ionizing radiation.
|Title:||Roles of the Major, Small, Acid-Soluble Spore Proteins and Spore-Specific and Universal DNA Repair Mechanisms in Resistance of Bacillus subtilis Spores to Ionizing Radiation from X Rays and High-Energy Charged-Particle Bombardment|
|Journal or Publication Title:||JOURNAL OF BACTERIOLOGY|
|In ISI Web of Science:||Yes|
|Page Range:||pp. 1134-1140|
|Publisher:||American Society for Microbiology|
|Keywords:||Bacillus subtilis, HZE, X-Rays, DNA repair|
|HGF - Research field:||Aeronautics, Space and Transport (old)|
|HGF - Program:||Space (old)|
|HGF - Program Themes:||W FR - Forschung unter Weltraumbedingungen (old)|
|DLR - Research area:||Space|
|DLR - Program:||W FR - Forschung unter Weltraumbedingungen|
|DLR - Research theme (Project):||W - Vorhaben Strahlenbiologie (old)|
|Institutes and Institutions:||Institute of Aerospace Medicine > Radiation Biology|
|Deposited By:||Kerstin Kopp|
|Deposited On:||19 Jun 2008|
|Last Modified:||27 Apr 2009 14:58|
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