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Influence of post-exercise tissue-reoxygenation on phosphocreatine recovery after static and dynamic calf muscle exercise in human

Zange, Jochen und Hallen, Ulrich und Müller, Klaus und Essfeld, Dieter (2005) Influence of post-exercise tissue-reoxygenation on phosphocreatine recovery after static and dynamic calf muscle exercise in human. In: Proceedings of the 9th European Symposium on Life Sciences Research & 26th Annual International Gravitational Physiology Meeting. 9th European Symposium on Life Sciences Research & 26th Annual International Gravitational Physiology Meeting, 2005-06-26 - 2005-07-01, Köln.

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Kurzfassung

During recovery from muscle contraction orthostasis simulated by LBNP in comparison with horizontal body position reduces the time constant of phosphocreatine resynthesis (tau<sub>PCr</sub>). This time constant reflects the rate of mitochondrial ATP formation. Recovery from exercise is accompanied by a reactive hyperemia. During recovery LBNP further increases blood volume but not flow. It is a common assumption, that after muscle contraction the increased blood flow alone results in a non-limiting oxygen supply for ATP formation during recovery. How can the increased blood volume by orthostasis enhance the rate of mitochondrial ATP formation? The following study tested the dogma about oxygen supply during recovery from exercise. <sup>31</sup>Phosphorus magnetic resonance spectroscopy (<sup>31</sup>P MRS) and near infrared spectroscopy (NIRS) were simultaneously applied to study oxidative phosphorylation during contraction and recovery. Seven healthy subjects performed with their right calf muscles dynamic and static plantar flexions during arterial occlusion until PCr concentrations were reduced to 40 % of their resting values. Oxygen consumption measured by NIRS immediately increased with the onset of contraction and was about 4 times higher during dynamic exercise than during static contraction. After a linear initial phase the rate of oxygen consumption slowly decreased, but significant rates were still observed after 2 min of ischemic exercise. This time course was found to be incompatible with the frequently used model supposing a Michaelis-Menten type control by free cytosolic ADP and inorganic phosphate. Moreover, the time constants of PCr recovery (tau<sub>PCr</sub>) after dynamic and static exercise were not different. So we failed to observe different recovery kinetics for different sub-populations of motor units with different mitochondrial densities. After both modes of exercise, tau<sub>PCr</sub> was positively correlated with the time constant of hemoglobin and myoglobin reoxygenation (tau<sub>Hb/MbO2</sub>). For slower PCr resynthesis (tau<sub>PCr</sub> > 40s) both time constants approached the identity line which suggests limiting influence of the rate of tissue reoxygenation on the rate of mitochondrial ATP formation. Therefore, mitochondrial oxygen supply cannot be neglected as a rate controlling factor in mitochondrial ATP formation during recovery from contraction in healthy muscle.

Dokumentart:Konferenzbeitrag (Vortrag)
Titel:Influence of post-exercise tissue-reoxygenation on phosphocreatine recovery after static and dynamic calf muscle exercise in human
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Zange, JochenNICHT SPEZIFIZIERT
Hallen, UlrichDeutsche Sporthochschule Köln
Müller, KlausNICHT SPEZIFIZIERT
Essfeld, DieterDeutsche Sporthochschule Köln
Datum:2005
Erschienen in:Proceedings of the 9th European Symposium on Life Sciences Research & 26th Annual International Gravitational Physiology Meeting
Referierte Publikation:Ja
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:NMR, Magnetresonanzspektroskopie, Muskelstoffwechsel, Muskeltraining
Veranstaltungstitel:9th European Symposium on Life Sciences Research & 26th Annual International Gravitational Physiology Meeting
Veranstaltungsort:Köln
Veranstaltungsart:internationale Konferenz
Veranstaltungsdatum:2005-06-26 - 2005-07-01
Veranstalter :International Society of Gravitational Physiology, ESA
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W -- keine Zuordnung (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Dr.rer.nat. Jochen Zange
Hinterlegt am:10 Jan 2006
Letzte Änderung:27 Apr 2009 04:52

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