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Influences of Experimental Air Pollution on Human Sympathetic Nerve Traffic and Norepinephrine Metabolism: A Double Blind, Randomized, Twofold Crossover Study

Tank, J. and Heusser, K. and Holz, O. and May, M. and Brinkmann, J. and Diedrich, A. and Framke, T. and Koch, A. and Grosshenning, A. and Sweep, F.C.G.J. and Koch, W. and Krug, N. and Jordan, J. and Hohlfeld, J. M. (2017) Influences of Experimental Air Pollution on Human Sympathetic Nerve Traffic and Norepinephrine Metabolism: A Double Blind, Randomized, Twofold Crossover Study. FASEB JOURNAL. Federation of American Societies for Experimental Biology. DOI: 10.1096/fasebj.31.1_supplement.675.8 ISSN 0892-6638

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Official URL: https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.675.8

Abstract

Background Much of the evidence linking air pollutant exposure with changes in human cardiovascular autonomic regulation relied on epidemiological studies, exposure estimates, and indirect autonomic nervous system measurements. We tested the hypothesis that in healthy older individuals, experimental exposure to fine particles increases sympathetic nervous system activity and more so with addition of ozone. Material and Methods Eighteen healthy participants (age >50 years) completed all study visits and were included in the final analysis. Participants were exposed to clean air (‘placebo’), ultrafine particles (UFP, 50μg/m3), and combination of UFP+ozone (250 ppb) for 3 hours combined with intermittent bicycle ergometer training in a randomized, three-period, cross-over, double-blind fashion. Three hours following exposure, respiration, ECG, blood pressure, and muscle sympathetic nerve activity (MSNA) were continuously recorded at supine rest, during deep breathing, and during a Valsalva maneuver. Venous blood samples for plasma catecholamine measurements were taken at baseline. Induced sputum was obtained at the end of each study day. Results Combined exposure to ozone and UFP but not UFP alone caused a significant increase in sputum neutrophils and circulating leucocytes. We did not detect significant effects on blood pressure or heart rate. Resting MSNA was 47±12 with clean air, 47±14 with UFP, and 45±14 bursts/min with UFP+ozone. Maximum MSNA during Valsalva phase IIb was similar. Yet, with UFP+ozone plasma norepinephrine concentrations were significantly increased with concomitant reduction in the dihydroxyphenylglycol (DHPG)/norepinephrine ratio. Respiratory sinus arrhythmia and Valsalva ratio were unaffected by experimental air pollution. Conclusion Exposure to ultrafine particles with or without ozone does not elicit clinically relevant changes in central sympathetic or parasympathetic activity in healthy older subjects. The paradoxical norepinephrine increase with UFP+ozone may be explained by reduced peripheral norepinephrine uptake and metabolism.

Item URL in elib:https://elib.dlr.de/126242/
Document Type:Article
Title:Influences of Experimental Air Pollution on Human Sympathetic Nerve Traffic and Norepinephrine Metabolism: A Double Blind, Randomized, Twofold Crossover Study
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Tank, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Holz, O.Clinical Airway Research, Fraunhofer ITEM, Hannoverhttps://orcid.org/0000-0003-0665-7807
May, M.Clinical Research Center, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Brinkmann, J.Institute for Clinical Pharmacology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNUNSPECIFIED
Framke, T.Institute for Biometry, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Koch, A.Institute for Biometry, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Grosshenning, A.Institute for Biometry, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Sweep, F.C.G.J.Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, NetherlandsUNSPECIFIED
Koch, W.Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, GermanyUNSPECIFIED
Krug, N.Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, GermanyUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Hohlfeld, J. M.Clinical Airway Research, Fraunhofer ITEM, HannoverUNSPECIFIED
Date:1 April 2017
Journal or Publication Title:FASEB JOURNAL
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1096/fasebj.31.1_supplement.675.8
Publisher:Federation of American Societies for Experimental Biology
ISSN:0892-6638
Status:Published
Keywords:Experimental Air Pollution; Human Sympathetic Nerve Traffic; Crossover Study
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:05 Feb 2019 08:51
Last Modified:05 Feb 2019 08:51

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