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Deciphering the neural signature of human blood pressure control

Manuel, J. and Nazarenko, N. and Heusser, K. and Tank, J. and Jordan, J. and Beissner, F. (2018) Deciphering the neural signature of human blood pressure control. FASEB JOURNAL. Federation of American Societies for Experimental Biology. ISSN 0892-6638

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Official URL: https://www.fasebj.org/doi/10.1096/fasebj.2018.32.1_supplement.714.12

Abstract

The aim of this study was to measure the activity of hypothalamic and brainstem centers regulating blood pressure in humans. The human body has several systems to regulate blood pressure, one of which is the baroreflex. It is mediated by a number of nuclei in the brainstem and hypothalamus that via autonomic efferents adjust the mean arterial pressure by altering both the force and speed of the heart’s contractions, as well as systemic vascular resistance. While cortical centers influencing the baroreflex have been studied in humans using functional magnetic resonance imaging (fMRI), the brainstem region suffers from strong physiological noise that makes detection more difficult. Here, we combined high-resolution fMRI with lower body negative pressure (LBNP) and concomitant autonomic recordings hypothesizing that such an approach would make it possible to detect hypothalamic and brainstem nuclei controlling the baroreflex in humans. 15 healthy subjects were scanned using a 3T MR scanner. The protocol involved SMS-EPI functional scans (voxel size=2×2×2 mm3) as well as T1-weighted structural scans (voxel size=1*1*1.2 mm3). LBNP stimulation was delivered using a custom-made MR-compatible pressure chamber and a vacuum cleaner that was controlled by a digital pressure gauge. FMRI data were minimally preprocessed using tools from FMRIB Software Library (FSL v5.0) including motion correction, unwarping, temporal high-pass filtering and normalization to a study template. The data were masked to retain only the brainstem and hypothalamus, excluding the adjacent areas with high physiological noise. Statistical analysis was conducted using masked independent component analysis (mICA), spectral analysis, and network modelling. We found activations related to the LBNP paradigm in multiple nuclei known to be involved in baroreflex regulation. These included the nucleus of the solitary tract and the caudal ventrolateral medulla in the lower brainstem as well as the paraventricular hypothalamic nucleus and lateral hypothalamus. We further observed significant activity changes on the lower ventral medullary surface. Frequency analysis revealed that the BOLD signal in the rostroventrolateral medulla showed spectral changes in the Mayer band (0.1 ± 0.035 Hz) during LBNP. Being able to measure baroreflex nuclei in vivo is an important step towards the understanding of this system in humans. Our results show the importance of selected nuclei in the hypothalamus and brainstem.

Item URL in elib:https://elib.dlr.de/126091/
Document Type:Article
Title:Deciphering the neural signature of human blood pressure control
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Manuel, J.Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Nazarenko, N.Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Heusser, K.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Tank, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Beissner, F.Institute for Neuroradiology, Hannover Medical School, Hannover, GermanyUNSPECIFIED
Date:20 April 2018
Journal or Publication Title:FASEB JOURNAL
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Publisher:Federation of American Societies for Experimental Biology
ISSN:0892-6638
Status:Published
Keywords:Deciphering; activity; hypothalamic; brainstem; blood pressure
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:24 Jan 2019 10:42
Last Modified:24 Jan 2019 10:42

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