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Simulation of microgravity for studies in gravitational biology: principles, devices and applications

Anken, Ralf (2013) Simulation of microgravity for studies in gravitational biology: principles, devices and applications. Current Biotechnology, 2 (3), pp. 192-200. Bentham Science. DOI: 10.2174/22115501113029990012. ISBN ISSN: 2211-5501, eISSN: 2211-551X. ISSN 2211-5501.

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Official URL: http://benthamscience.com/journal/index.php?journalID=cbiot

Abstract

Scientists and technicians have been innovative to develop experimental platforms in order to achieve functional weightless conditions in their Earth-bound laboratories. As a result, various experimental platforms are available in order to perform studies with molecules or single cells up to humans and to study gravity-related mechanisms. These ground-based simulators of microgravity are not only tools to prepare spaceflight experiments, but they have been established as stand-alone facilities for gravitational research. This review provides an overview of some of the most frequently used microgravity simulators, most of which are in use at DLR´s Institute of Aerospace Medicine at Cologne, Germany. Their individual capacities but also experimental limitations, especially regarding their range of applicability for biological specimens, are exemplarily reviewed here. Overall, it is necessary to compare data achieved by using simulators with the data obtained in real microgravity. Furthermore, it should be carefully considered which kind of simulation might be the optimum for a given model organism or cell.

Document Type:Article
Title:Simulation of microgravity for studies in gravitational biology: principles, devices and applications
Authors:
AuthorsInstitution or Email of Authors
Anken, RalfGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany
Date:2013
Journal or Publication Title:Current Biotechnology
Refereed publication:Yes
In Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Volume:2
DOI:10.2174/22115501113029990012
Page Range:pp. 192-200
Editors:
EditorsEmail
Dalby, PaulDept of Biochemical Engineering, University College London Torrington Place, WC1E 7JE, UK
Publisher:Bentham Science
ISSN:2211-5501
ISBN:ISSN: 2211-5501, eISSN: 2211-551X
Status:Published
Keywords:Space Biology, Gravitational Biology, Gravity, Microgravity, Clinostat, Random Positioning Machine
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Biomedical Science Support Center
Deposited By: Ralf Anken
Deposited On:10 Feb 2014 09:16
Last Modified:10 Feb 2014 09:16

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