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Cellular Response to Exposure with Different Radiation Qualities with a Focus on Nuclear Factor kB

Hellweg, Christine E. (2012) Cellular Response to Exposure with Different Radiation Qualities with a Focus on Nuclear Factor kB. Habilitation, Freie Universität Berlin.

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Abstract

Understanding the cellular radiation response is an essential prerequisite for the risk assessment of astronauts’ space radiation exposure during long-term space missions and for effective countermeasure development. The same holds for improving cancer radiotherapy, including carbon ion therapy. Space radiation exposure bears two major risks: large solar particle events (SPE) might cause the acute radiation syndrome, and the chronic exposure to galactic cosmic rays (GCR) increases the cancer and cataract risk. Energetic heavy ions as GCR components are of major importance because of their high relative biological effectiveness (RBE). The cellular radiation response involves a complex network of signaling pathways, which result in cell-protective (DNA repair, cell cycle arrest) or cell-destructive (cell death) reactions. The central role of p53 in the radiation response was recognized early, while in radiobiological research, the Nuclear Factor kB (NF-kB) pathway was less investigated. NF-kB is a central transcription factor in the immune system and in inflammation, and exhibits pro-survival effects. Especially its activation in response to space relevant radiation qualities and carbon ion therapy needs to be known. Furthermore, possible combined effects of radiation and other spaceflight environmental factors such as microgravity on the NF-kB pathway are unknown.

Document Type:Thesis (Habilitation)
Title:Cellular Response to Exposure with Different Radiation Qualities with a Focus on Nuclear Factor kB
Authors:
AuthorsInstitution or Email of Authors
Hellweg, Christine E.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
Date:2012
Refereed publication:No
Number of Pages:353
Status:Published
Keywords:Nuclear Factor kB (NF-kB), space radiation exposure, cancer radiotherapy, carbon ion therapy, cellular response
Institution:Freie Universität Berlin
Department:Fachbereich Veterinärmedizin der Freien Universität Berlin - Institut für Immunologie
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kerstin Kopp
Deposited On:28 Feb 2013 09:12
Last Modified:28 Feb 2013 09:12

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