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Sensitivity of Adipose Tissue-Derived Stem Cells in Response to Ionizing Radiation in the Context of Osteoblastic Differentiation

Lingner, Tom (2012) Sensitivity of Adipose Tissue-Derived Stem Cells in Response to Ionizing Radiation in the Context of Osteoblastic Differentiation. Bachelorarbeit, University of Applied Science Bonn-Rhein-Sieg.

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Kurzfassung

Humans travelling in space are exposed to a constant threat from ionizing radiation from both solar- and cosmic sources. These irradiations pose a threat to cells in various tissues of the human body. One example for this is bone tissue where the sensible balance of bone formation and -resorption may be affected by ionizing radiation. A basic radiobiological characterisation of a set of mesenchymal stem cells derived from human adipose tissue in comparison to an osteosarcoma derived cell line was done. X-rays were used as a substitute for space radiation. Growth characteristics, osteoblastic differentiation potential, colony forming ability after irradiation, DNA double strand break repair after irradiation as well as cell cycle progression after irradiation were determined. It was shown that adipose tissue derived stem cells as well as the osteosarcoma derived cell line feature the potential of osteoblastic differentiation and are able to cope with low doses of X-rays relatively well because of their repair- and recovery potential. However higher doses of X-rays exert devastating effects on proliferation potential and cell cycle regulation, while the cancer cells were slightly more resistant to irradiation than the stem cells.

Dokumentart:Hochschulschrift (Bachelorarbeit)
Titel:Sensitivity of Adipose Tissue-Derived Stem Cells in Response to Ionizing Radiation in the Context of Osteoblastic Differentiation
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Lingner, Tom Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
Datum:2012
Seitenanzahl:69
Status:veröffentlicht
Stichwörter:ionizing radiation, adipose tissue-derived stem cells, osteosarcoma derived cell line, X-rays
Institution:University of Applied Science Bonn-Rhein-Sieg
Abteilung:Department of Natural Sciences
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr, Verkehr und Weltraum (alt)
HGF - Programm:Raumfahrt, Weltraum (alt)
HGF - Programmthema:Forschung unter Weltraumbedingungen, W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Raumfahrt, Weltraum
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen, W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Strahlenbiologie, W - Vorhaben Strahlenbiologie (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kerstin Kopp
Hinterlegt am:10 Sep 2012 15:35
Letzte Änderung:10 Sep 2012 15:35

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