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Role of altered rpoB alleles in Bacillus subtilis sporulation and spore resistance to heat, hydrogen peroxide, formaldehyde, and glutaraldehyde.

Moeller, Ralf and Vlašić , Ignacija and Reitz, Guenther and Nicholson, Wayne L. (2012) Role of altered rpoB alleles in Bacillus subtilis sporulation and spore resistance to heat, hydrogen peroxide, formaldehyde, and glutaraldehyde. Archives of Microbiology, 194 (9), pp. 759-767. Springer Verlag. DOI: 10.1007/s00203-012-0811-4. ISSN 0302-8933.

Full text not available from this repository.

Abstract

Mutations in the RNA polymerase β-subunit gene rpoB causing resistance to rifampicin (Rif^R) in Bacillus subtilis were previously shown to lead to alterations in the expression of a number of global phenotypes known to be under transcriptional control. To better understand the influence of rpoB mutations on sporulation and spore resistance to heat and chemicals, cells and spores of the wild-type and twelve distinct congenic Rif^R mutant strains of B. subtilis were tested. Different levels of glucose catabolite repression during sporulation and spore resistance to heat and chemicals were observed in the Rif^R mutants, indicating the important role played by the RNA polymerase β-subunit, not only in the catalytic aspect of transcription, but also in the initiation of sporulation and in the spore resistance properties of B. subtilis.

Document Type:Article
Title:Role of altered rpoB alleles in Bacillus subtilis sporulation and spore resistance to heat, hydrogen peroxide, formaldehyde, and glutaraldehyde.
Authors:
AuthorsInstitution or Email of Authors
Moeller, RalfResearch Group 'Astrobiology', Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Hoehe, 51147 Cologne, Germany
Vlašić , IgnacijaLaboratory of Evolutionary Genetics, Division of Molecular Biology, Ruder Bošković Institute, Zagreb, Croatia
Reitz, GuentherRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Hoehe, 51147 Cologne, Germany
Nicholson, Wayne L. Space Life Sciences Laboratory, Department of Microbiology and Cell Science, University of Florida, Kennedy Space Center, FL, USA
Date:2012
Journal or Publication Title:Archives of Microbiology
Refereed publication:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:194
DOI:10.1007/s00203-012-0811-4
Page Range:pp. 759-767
Publisher:Springer Verlag
ISSN:0302-8933
Status:Published
Keywords:Bacillus subtilis, Sporulation, Spore resistance, Heat, Chemicals
HGF - Research field:Aeronautics, Space and Transport, Aeronautics, Space and Transport (old)
HGF - Program:Space, Space (old)
HGF - Program Themes:Research under Space Conditions, W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Raumfahrt, Space
DLR - Program:R FR - Forschung unter Weltraumbedingungen, W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie, W - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kerstin Kopp
Deposited On:17 Aug 2012 11:18
Last Modified:20 Mar 2013 19:45

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