Moeller, Ralf and Vlašić , Ignacija and Reitz, Guenther and Nicholson, Wayne L. (2012) Role of altered rpoB alleles in Bacillus subtilis sporulation and spore resistance to heat, hydrogen peroxide, formaldehyde, and glutaraldehyde. Archives of Microbiology, 194 (9), pp. 759-767. Springer Verlag. DOI: 10.1007/s00203-012-0811-4. ISSN 0302-8933.
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Mutations in the RNA polymerase β-subunit gene rpoB causing resistance to rifampicin (Rif^R) in Bacillus subtilis were previously shown to lead to alterations in the expression of a number of global phenotypes known to be under transcriptional control. To better understand the influence of rpoB mutations on sporulation and spore resistance to heat and chemicals, cells and spores of the wild-type and twelve distinct congenic Rif^R mutant strains of B. subtilis were tested. Different levels of glucose catabolite repression during sporulation and spore resistance to heat and chemicals were observed in the Rif^R mutants, indicating the important role played by the RNA polymerase β-subunit, not only in the catalytic aspect of transcription, but also in the initiation of sporulation and in the spore resistance properties of B. subtilis.
|Title:||Role of altered rpoB alleles in Bacillus subtilis sporulation and spore resistance to heat, hydrogen peroxide, formaldehyde, and glutaraldehyde.|
|Journal or Publication Title:||Archives of Microbiology|
|In ISI Web of Science:||Yes|
|Page Range:||pp. 759-767|
|Keywords:||Bacillus subtilis, Sporulation, Spore resistance, Heat, Chemicals|
|HGF - Research field:||Aeronautics, Space and Transport, Aeronautics, Space and Transport (old)|
|HGF - Program:||Space, Space (old)|
|HGF - Program Themes:||Research under Space Conditions, W FR - Forschung unter Weltraumbedingungen (old)|
|DLR - Research area:||Raumfahrt, Space|
|DLR - Program:||R FR - Forschung unter Weltraumbedingungen, W FR - Forschung unter Weltraumbedingungen|
|DLR - Research theme (Project):||R - Vorhaben Strahlenbiologie, W - Vorhaben Strahlenbiologie (old)|
|Institutes and Institutions:||Institute of Aerospace Medicine > Radiation Biology|
|Deposited By:||Kerstin Kopp|
|Deposited On:||17 Aug 2012 11:18|
|Last Modified:||20 Mar 2013 19:45|
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