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Out-of-field dose studies with an anthropomorphic phantom: Comparison of X-rays and particle therapy treatments

La Tessa, Chiara und Berger, Thomas und Kaderka, Robert und Schardt, Dieter und Körner, Christine und Ramm, Ulla und Licher, Jörg und Matsufuji, Nakahiro und Vallhagen Dahlgren, Christina und Lomax, Tony und Reitz, Günther und Durante, Marco (2012) Out-of-field dose studies with an anthropomorphic phantom: Comparison of X-rays and particle therapy treatments. Radiotherapy and Oncology, 105 (1), Seiten 133-138. Elsevier. DOI: 10.1016/j.radonc.2012.04.004.

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Kurzfassung

Background and purpose: Characterization of the out-of-field dose profile following irradiation of the target with a 3D treatment plan delivered with modern techniques. Methods: An anthropomorphic RANDO phantom was irradiated with a treatment plan designed for a simulated 5 x 2 x 5 cm³ tumor volume located in the center of the head. The experiment was repeated with all most common radiation treatment types (photons, protons and carbon ions) and delivery techniques (Intensity Modulated Radiation Therapy, passive modulation and spot scanning). The measurements were performed with active diamond detector and passive thermoluminescence (TLD) detectors to investigate the out-of-field dose both inside and outside the phantom. Results: The highest out-of-field dose values both on the surface and inside the phantom were measured during the treatment with 25 MV photons. In the proximity of the Planned Target Volume (PTV), the lowest lateral dose profile was observed for passively modulated protons mainly because of the presence of the collimator in combination with the chosen volume shape. In the far out-of-field region (above 100 mm from the PTV), passively modulated ions were characterized by a less pronounced dose falloff in comparison with scanned beams. Overall, the treatment with scanned carbon ions delivered the lowest dose outside the target volume. Conclusions: For the selected PTV, the use of the collimator in proton therapy drastically reduced the dose deposited by ions or photons nearby the tumor. Scanning modulation represents the optimal technique for achieving the highest dose reduction far-out-of-field.

Dokumentart:Zeitschriftenbeitrag
Titel:Out-of-field dose studies with an anthropomorphic phantom: Comparison of X-rays and particle therapy treatments
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
La Tessa, Chiara GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany
Berger, Thomas Institute of Aerospace Medicine, Cologne, Germany
Kaderka, Robert GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany
Schardt, Dieter GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany
Körner, Christine Institute of Aerospace Medicine, Cologne, Germany
Ramm, Ulla Johann Wolfgang Goethe Universität, Frankfurt/Main, Germany
Licher, Jörg Johann Wolfgang Goethe Universität, Frankfurt/Main, Germany
Matsufuji, Nakahiro National Institute of Radiological Sciences, Chiba, Japan
Vallhagen Dahlgren, Christina Uppsala University Hospital, Sweden
Lomax, Tony Paul Scherrer Institute, Villigen, Switzerland
Reitz, Günther Institute of Aerospace Medicine, Cologne, Germany
Durante, Marco GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany and Technische Universität Darmstadt, Germany
Datum:2012
Erschienen in:Radiotherapy and Oncology
Referierte Publikation:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:105
DOI :10.1016/j.radonc.2012.04.004
Seitenbereich:Seiten 133-138
Verlag:Elsevier
Status:veröffentlicht
Stichwörter:X-rays, Protons, Carbon ions, Hadrontherapy, Out-of-field dose
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Strahlenbiologie
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kerstin Kopp
Hinterlegt am:17 Aug 2012 11:21
Letzte Änderung:04 Apr 2013 16:38

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