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The effects of bed rest and countermeasure exercise on the endocrine system in male adults: Evidence for immobilization-induced reduction in sex hormone-binding globulin levels

Belavy, Daniel Ludovic and Seibel, Markus and Roth, H.J. and Armbrecht, Gabriele and Rittweger, Jörn and Felsenberg, Dieter (2012) The effects of bed rest and countermeasure exercise on the endocrine system in male adults: Evidence for immobilization-induced reduction in sex hormone-binding globulin levels. Journal of Endocrinological Investigation, 35, pp. 54-62. ISSN 0391-4097.

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Abstract

Background and Aim. There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and after prolonged (56-day) bed-rest in male adults. Subjects and Methods. 20 healthy male subjects underwent 8 weeks of strict bed-rest and 12 months follow-up as part of the Berlin Bed-Rest Study. Subjects were randomised to an inactive group or a group that performed resistive vibration exercise (RVE) during bed-rest. All outcome parameters were measured before, during and after bed-rest. These included body composition (by whole body dual X-ray absorptiometry), sex hormone-binding globulin (SHBG), testosterone (T), estradiol (E2), prolactin (PRL), cortisol (C), thyroid stimulating hormone (TSH) and free triiodothyronine (FT3). Results. Serum SHBG levels decreased in inactive subjects but remained unchanged in the RVE group (p<.001). Serum T concentrations increased during the first 3-weeks of bed-rest in both groups (p<.0001), while E2 levels sharply rose with re-mobilisation (p<.0001). Serum PRL decreased in the CTRL group but increased in the RVE group (p=.021). C levels did not change over time (p≥.10). TSH increased whilst FT3 decreased during bed-rest (p all≤.0013). Conclusions. Prolonged bed-rest has significant effects on parameters of endocrine and metabolic function, some of which are related to, or counteracted by physical activity.

Document Type:Article
Title:The effects of bed rest and countermeasure exercise on the endocrine system in male adults: Evidence for immobilization-induced reduction in sex hormone-binding globulin levels
Authors:
AuthorsInstitution or Email of Authors
Belavy, Daniel LudovicCharité Campus Benjamin Franklin
Seibel, MarkusUniversity of Sydney
Roth, H.J.Labor Limbach
Armbrecht, GabrieleCharité Campus Benjamin Franklin
Rittweger, Jörnjoern.rittweger@dlr.de
Felsenberg, DieterCharité Campus Benjamin Franklin
Date:2012
Journal or Publication Title:Journal of Endocrinological Investigation
Refereed publication:Yes
In SCOPUS:Yes
In ISI Web of Science:No
Volume:35
Page Range:pp. 54-62
ISSN:0391-4097
Status:Published
Keywords:Spaceflight, microgravity, inactivity, Berlin Bed Rest study
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Jörn Rittweger
Deposited On:08 Mar 2012 11:18
Last Modified:17 Jun 2014 03:02

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