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Is the myonuclear domain size fixed?

Van der Meer, S.F. and Degens, H. (2011) Is the myonuclear domain size fixed? Journal of Musculoskeletal and Neuronal Interactions, 11 (4). ISSN 1108-7161.

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Abstract

It has been suggested that the number of myonuclei in a muscle fibre changes in proportion to the change in fibre size, resulting in a constant myonuclear domain size, defined as the cytoplasmic volume per myonucleus. The myonuclear domain size varies, however, between fibre types and is inversely related with the oxidative capacity of a fibre. Overall, the observations of an increase in myonuclear domain size during both maturational growth and overload-induced hypertrophy, and the decrease in myonuclear domain size during disuse- and ageing-associated muscle atrophy suggest that the concept of a constant myonuclear domain size needs to be treated cautiously. It also suggests that only when the myonuclear domain size exceeds a certain threshold during growth or overload-induced hypertrophy acquisition of new myonuclei is required for further fibre hypertrophy.

Document Type:Article
Title:Is the myonuclear domain size fixed?
Authors:
AuthorsInstitution or Email of Authors
Van der Meer, S.F.UNSPECIFIED
Degens, H.UNSPECIFIED
Date:December 2011
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
In ISI Web of Science:Yes
Volume:11
ISSN:1108-7161
Status:Published
Keywords:Skeletal Muscle Myonuclear Domain Satellite Cell Hypertrophy Atrophy Ageing Growth
HGF - Research field:other
HGF - Program:other
HGF - Program Themes:other
DLR - Research area:no assignement
DLR - Program:no assignment
DLR - Research theme (Project):other
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Klaus Müller
Deposited On:30 Jan 2012 11:23
Last Modified:07 Feb 2013 19:27

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