Is the myonuclear domain size fixed?
Van der Meer, S.F. and Degens, H. (2011) Is the myonuclear domain size fixed? Journal of Musculoskeletal and Neuronal Interactions, 11 (4). ISSN 1108-7161.
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It has been suggested that the number of myonuclei in a muscle fibre changes in proportion to the change in fibre size, resulting in a constant myonuclear domain size, defined as the cytoplasmic volume per myonucleus. The myonuclear domain size varies, however, between fibre types and is inversely related with the oxidative capacity of a fibre. Overall, the observations of an increase in myonuclear domain size during both maturational growth and overload-induced hypertrophy, and the decrease in myonuclear domain size during disuse- and ageing-associated muscle atrophy suggest that the concept of a constant myonuclear domain size needs to be treated cautiously. It also suggests that only when the myonuclear domain size exceeds a certain threshold during growth or overload-induced hypertrophy acquisition of new myonuclei is required for further fibre hypertrophy.
|Title:||Is the myonuclear domain size fixed?|
|Journal or Publication Title:||Journal of Musculoskeletal and Neuronal Interactions|
|In ISI Web of Science:||Yes|
|Keywords:||Skeletal Muscle Myonuclear Domain Satellite Cell Hypertrophy Atrophy Ageing Growth|
|HGF - Research field:||no assignement|
|HGF - Program:||no assignment|
|HGF - Program Themes:||no assignment|
|DLR - Research area:||no assignement|
|DLR - Program:||no assignment|
|DLR - Research theme (Project):||other|
|Institutes and Institutions:||Institute of Aerospace Medicine > Space Physiology|
|Deposited By:||Klaus Müller|
|Deposited On:||30 Jan 2012 11:23|
|Last Modified:||07 Feb 2013 19:27|
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