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Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest

Belavy, Daniel Ludovic und Bansmann, Martin und Böhme, Gisela und Frings-Meuthen, Petra und Heer, Martina und Rittweger, Jörn und Zange, Jochen und Felsenberg, Dieter (2011) Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest. Journal of Applied Physiology, 111, Seiten 1304-1314. ISSN 8750-7587.

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Kurzfassung

As part of the nutrition- countermeasures (NUC) study in Cologne, Germany in 2010, seven healthy male subjects underwent 21 days of head-down tilt bed rest and returned 153 days later to undergo a second bout of 21-day bed rest. As part of this model, we aimed to examine the recovery of the lumbar intervertebral discs and muscle cross-sectional area (CSA) after bed rest using magnetic resonance imaging and conduct a pilot study on the effects of bed rest in lumbar muscle activation, as measured by signal intensity changes in T2-weighted images after a standardized isometric spinal extension loading task. The changes in intervertebral disc volume, anterior and posterior disc height, and intervertebral length seen after bed rest did not return to prebed-rest values 153 days later. While recovery of muscle CSA occurred after bed rest, increases (P  0.016) in multifidus, psoas, and quadratus lumborum muscle CSA were seen 153 days after bed rest. A trend was seen for greater activation of the erector spinae and multifidus muscles in the standardized loading task after bed rest. Greater reductions of multifidus and psoas CSA muscle and greater increases in multifidus signal intensity with loading were associated with incidence of low back pain in the first 28 days after bed rest (P  0.044). The current study contributes to our understanding of the recovery of the lumbar spine after 21-day bed rest, and the main finding was that a decrease in spinal extensor muscle CSA recovers within 5 mo after bed rest but that changes in the intervertebral discs persist.

Dokumentart:Zeitschriftenbeitrag
Titel:Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Belavy, Daniel LudovicCharité Campus Benjamin Franklin
Bansmann, MartinKrankenhaus Porz
Böhme, Giselagisela.boehme@dlr.de
Frings-Meuthen, Petrapetra.frings-meuthen@dlr.de
Heer, MartinaProfil Research
Rittweger, Jörnjoern.rittweger@dlr.de
Zange, Jochenjochen.zange@dlr.de
Felsenberg, Dieterdieter.felsenberg@dlr.de
Datum:2011
Erschienen in:Journal of Applied Physiology
Referierte Publikation:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:111
Seitenbereich:Seiten 1304-1314
ISSN:8750-7587
Status:veröffentlicht
Stichwörter:magnetic resonance imaging; microgravity; spaceflight; low back pain; atrophy
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Jörn Rittweger
Hinterlegt am:06 Dez 2011 12:23
Letzte Änderung:07 Feb 2013 20:12

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