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Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest

Belavy, Daniel Ludovic and Bansmann, Martin and Böhme, Gisela and Frings-Meuthen, Petra and Heer, Martina and Rittweger, Jörn and Zange, Jochen and Felsenberg, Dieter (2011) Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest. Journal of Applied Physiology, 111, pp. 1304-1314. ISSN 8750-7587.

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Abstract

As part of the nutrition- countermeasures (NUC) study in Cologne, Germany in 2010, seven healthy male subjects underwent 21 days of head-down tilt bed rest and returned 153 days later to undergo a second bout of 21-day bed rest. As part of this model, we aimed to examine the recovery of the lumbar intervertebral discs and muscle cross-sectional area (CSA) after bed rest using magnetic resonance imaging and conduct a pilot study on the effects of bed rest in lumbar muscle activation, as measured by signal intensity changes in T2-weighted images after a standardized isometric spinal extension loading task. The changes in intervertebral disc volume, anterior and posterior disc height, and intervertebral length seen after bed rest did not return to prebed-rest values 153 days later. While recovery of muscle CSA occurred after bed rest, increases (P  0.016) in multifidus, psoas, and quadratus lumborum muscle CSA were seen 153 days after bed rest. A trend was seen for greater activation of the erector spinae and multifidus muscles in the standardized loading task after bed rest. Greater reductions of multifidus and psoas CSA muscle and greater increases in multifidus signal intensity with loading were associated with incidence of low back pain in the first 28 days after bed rest (P  0.044). The current study contributes to our understanding of the recovery of the lumbar spine after 21-day bed rest, and the main finding was that a decrease in spinal extensor muscle CSA recovers within 5 mo after bed rest but that changes in the intervertebral discs persist.

Document Type:Article
Title:Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest
Authors:
AuthorsInstitution or Email of Authors
Belavy, Daniel LudovicCharité Campus Benjamin Franklin
Bansmann, MartinKrankenhaus Porz
Böhme, Giselagisela.boehme@dlr.de
Frings-Meuthen, Petrapetra.frings-meuthen@dlr.de
Heer, MartinaProfil Research
Rittweger, Jörnjoern.rittweger@dlr.de
Zange, Jochenjochen.zange@dlr.de
Felsenberg, Dieterdieter.felsenberg@dlr.de
Date:2011
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:111
Page Range:pp. 1304-1314
ISSN:8750-7587
Status:Published
Keywords:magnetic resonance imaging; microgravity; spaceflight; low back pain; atrophy
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Jörn Rittweger
Deposited On:06 Dec 2011 12:23
Last Modified:07 Feb 2013 20:12

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