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Effects of alfacalcidol on circulating cytokines and growth factors in rat skeletal muscle

Testerink, Janwillem und Jaspers, Richard und Rittweger, Jörn und de Haan, Arnold und Degens, Hans (2011) Effects of alfacalcidol on circulating cytokines and growth factors in rat skeletal muscle. Journal of Physiological Sciences, 61, Seiten 525-535. ISSN 1880-6546.

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Kurzfassung

Abstract Supra-physiological levels of vitamin D induce skeletal muscle atrophy, which may be particularly detrimental in already sarcopaenic elderly. Neither the cause nor whether the atrophy is fibre type specific are known. To obtain supraphysiological levels of circulating vitamin D (1,25(OH)2D3) 27.5-month-old female Fischer344 9 Brown Norway F1 rats were orally treated for 6 weeks with vehicle or the vitamin D analogue alfacalcidol. Alfacalcidol treatment induced a 22% decrease in body mass and 17% muscle atrophy. Fibre atrophy was restricted to type IIb fibres in the low-oxidative part of the gastrocnemius medialis only (-22%; P\0.05). There was a concomitant 1.6-fold increase in mRNA expression of the ubiquitin ligase MuRF-1 (P\0.001), whereas those of insulin-like growth factor 1 and myostatin were not affected. Circulating IL-6 was unaltered, but leptin and adiponectin were decreased (-39%) and increased (64%), respectively. The treated rats also exhibited a reduced food intake. In conclusion, supraphysiological levels of circulating 1,25(OH)2D3 cause preferential atrophy of type IIb fibres, which is associated with an increased expression of MuRF- 1 without evidence of systemic inflammation. The atrophy and loss of body mass in the presence of supra-physiological levels of vitamin D are primarily due to a reduced food intake.

Dokumentart:Zeitschriftenbeitrag
Titel:Effects of alfacalcidol on circulating cytokines and growth factors in rat skeletal muscle
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Testerink, JanwillemFree University Amsterdam
Jaspers, RichardFree University Amsterdam
Rittweger, Jörnjoern.rittweger@dlr.de
de Haan, ArnoldFree University Amsterdam
Degens, HansManchester Metropolitan University
Datum:2011
Erschienen in:Journal of Physiological Sciences
Referierte Publikation:Nein
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:61
Seitenbereich:Seiten 525-535
ISSN:1880-6546
Status:veröffentlicht
Stichwörter:Vitamin D, Atrophy, IGF-1, Myostatin, Aging, E3-ligase
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Jörn Rittweger
Hinterlegt am:06 Dez 2011 12:24
Letzte Änderung:12 Dez 2013 21:27

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