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Activation of the Nuclear Factor κB pathway by heavy ion beams of different linear energy transfer

Hellweg, Christine E. and Baumstark-Khan, Christa and Schmitz, Claudia and Lau, Patrick and Meier, Matthias M. and Testard, Isabelle and Berger, Thomas and Reitz, Günther (2011) Activation of the Nuclear Factor κB pathway by heavy ion beams of different linear energy transfer. International Journal of Radiation Biology, 87 (9), pp. 954-963. Informa Healthcare. DOI: 10.3109/09553002.2011.584942.

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Abstract

Purpose: Risk assessment of radiation exposure during long-term space missions requires the knowledge of the relative biological effectiveness (RBE) of space radiation components. Few data on gene transcription activation by different heavy ions are available, suggesting a dependence on linear energy transfer. The transcription factor Nuclear Factor κB (NF-κB) can be involved in cancerogenesis. Therefore, NF-κB activation by accelerated heavy ions of different linear energy transfer (LET) was correlated to survival. Materials and methods: NF-κB-dependent gene induction after exposure to heavy ions was detected in stably transfected human embryonic kidney 293 cells (HEK-pNF-κB-d2EGFP/Neo cells carrying a neomycin resistance), using the destabilized Enhanced Green Fluorescent Protein (d2EGFP) as reporter. Results: Argon (LET 272 keV/μm) and neon ions (LET 91 keV/μm) had the highest potential to activate NF-κB, resulting in a RBE of 8.9 in comparison to 150 kV X-rays. The RBE for survival also reached its maximum in this LET range, with a maximal value of 2. Conclusions: NF-κB might be involved in modulating survival responses of cells hit by heavy ions in the LET range of 91–272 keV/μm and could therefore become a factor to be considered for risk assessment of radiation exposure during space travel.

Document Type:Article
Title:Activation of the Nuclear Factor κB pathway by heavy ion beams of different linear energy transfer
Authors:
AuthorsInstitution or Email of Authors
Hellweg, Christine E.German Aerospace Centre (DLR), Institute of Aerospace Medicine, Radiation Biology, Linder Höhe, Köln, Germany
Baumstark-Khan, ChristaGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Radiation Biology, Linder Höhe, Köln, Germany
Schmitz, ClaudiaGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Radiation Biology, Linder Höhe, Köln, Germany
Lau, PatrickGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Radiation Biology, Linder Höhe, Köln, Germany
Meier, Matthias M.German Aerospace Centre (DLR), Institute of Aerospace Medicine, Radiation Biology, Linder Höhe, Köln, Germany
Testard, IsabelleLaboratoire d'Accueil en Radiobiologie avec les Ions Accélérés (LARIA), CEA, DVS/IRCM/SRO at the Centre de recherches sur les Ions, les Matériaux et la Photonique (CIMAP)/Grand Accélérateur National d'Ions Lourds (GANIL), Caen Cedex, France
Berger, ThomasGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Radiation Biology, Linder Höhe, Köln, Germany
Reitz, GüntherGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Radiation Biology, Linder Höhe, Köln, Germany
Date:2011
Journal or Publication Title:International Journal of Radiation Biology
Refereed publication:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:87
DOI:10.3109/09553002.2011.584942
Page Range:pp. 954-963
Publisher:Informa Healthcare
Status:Published
Keywords:Nuclear Factor κB, linear energy transfer, heavy ion, space mission, relative biological effectiveness
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kerstin Kopp
Deposited On:04 Nov 2011 11:37
Last Modified:04 Apr 2013 16:31

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