Hellweg, Christine E. and Baumstark-Khan, Christa and Schmitz, Claudia and Lau, Patrick and Meier, Matthias M. and Testard, Isabelle and Berger, Thomas and Reitz, Günther (2011) Activation of the Nuclear Factor κB pathway by heavy ion beams of different linear energy transfer. International Journal of Radiation Biology, 87 (9), pp. 954-963. Informa Healthcare. DOI: 10.3109/09553002.2011.584942.
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Purpose: Risk assessment of radiation exposure during long-term space missions requires the knowledge of the relative biological effectiveness (RBE) of space radiation components. Few data on gene transcription activation by different heavy ions are available, suggesting a dependence on linear energy transfer. The transcription factor Nuclear Factor κB (NF-κB) can be involved in cancerogenesis. Therefore, NF-κB activation by accelerated heavy ions of different linear energy transfer (LET) was correlated to survival. Materials and methods: NF-κB-dependent gene induction after exposure to heavy ions was detected in stably transfected human embryonic kidney 293 cells (HEK-pNF-κB-d2EGFP/Neo cells carrying a neomycin resistance), using the destabilized Enhanced Green Fluorescent Protein (d2EGFP) as reporter. Results: Argon (LET 272 keV/μm) and neon ions (LET 91 keV/μm) had the highest potential to activate NF-κB, resulting in a RBE of 8.9 in comparison to 150 kV X-rays. The RBE for survival also reached its maximum in this LET range, with a maximal value of 2. Conclusions: NF-κB might be involved in modulating survival responses of cells hit by heavy ions in the LET range of 91–272 keV/μm and could therefore become a factor to be considered for risk assessment of radiation exposure during space travel.
|Title:||Activation of the Nuclear Factor κB pathway by heavy ion beams of different linear energy transfer|
|Journal or Publication Title:||International Journal of Radiation Biology|
|In ISI Web of Science:||Yes|
|Page Range:||pp. 954-963|
|Keywords:||Nuclear Factor κB, linear energy transfer, heavy ion, space mission, relative biological effectiveness|
|HGF - Research field:||Aeronautics, Space and Transport|
|HGF - Program:||Space|
|HGF - Program Themes:||Research under Space Conditions|
|DLR - Research area:||Raumfahrt|
|DLR - Program:||R FR - Forschung unter Weltraumbedingungen|
|DLR - Research theme (Project):||R - Vorhaben Strahlenbiologie|
|Institutes and Institutions:||Institute of Aerospace Medicine > Radiation Biology|
|Deposited By:||Kerstin Kopp|
|Deposited On:||04 Nov 2011 11:37|
|Last Modified:||04 Apr 2013 16:31|
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