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Load-sensitive adhesion factor expression in the elderly with skiing: relation to fiber type and muscle strength

Flueck, Martin und Eyeang-Békalé, Nadège und Héraud, Audrey und Girard, Anne und Gimpl, Martin und Seynnes, Olivier und Rittweger, Jörn und Niebauer, Josef und Mueller, Erich und Narici, Marco (2011) Load-sensitive adhesion factor expression in the elderly with skiing: relation to fiber type and muscle strength. Scandinavian Journal of Medicine & Science in Sports, 23 (Suppl ), Seiten 29-38.

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We hypothesized that 3-months of downhill skiing mitigates functional deficits of knee extensor muscles in elderly subjects due to specific recruitment of fast motor units during forceful turns on the slope. Downhill skiing lead to a 1.4-fold increase in mean cross sectional area of slow (p=0.04) and fast (p=0.08) type muscle fibres. Fold changes in the structural component of focal adhesions, gamma-vinculin, correlated with alterations in concentric force (r=0.64). Hypertrophy of fast fibres was more important in women than in men (1.7 vs. 1.1). Gender specific structural-functional adjustments of extensor muscle and attached patellar tendon were reflected by altered expression of pro- vs. de-adhesive proteins and a number of correlations. The de-adhesive protein tenascin-C was selectively increased in women compared to men (1.7 vs. 1.1) while the content of the adhesive collagen XII was specifically reduced by 39% in women. The pro-adhesive focal adhesion kinase showed a specific increase in men (1.9 vs. 1.1). Our findings identify that quantitatively matched adaptations in slow and fast motor units underlie the preventive effect of skiing against sarcopenia and support that hypertrophy and reinforcement of fibre adhesion in extensor muscle are two myocellular strategies which operate in the improvement of muscle strength.

Dokumentart:Zeitschriftenbeitrag
Titel:Load-sensitive adhesion factor expression in the elderly with skiing: relation to fiber type and muscle strength
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Flueck, MartinManchester Metropolitan University
Eyeang-Békalé, NadègeManchester Metropolitan University
Héraud, AudreyManchester Metropolitan University
Girard, AnneManchester Metropolitan University
Gimpl, MartinUniversity of Salzburg
Seynnes, OlivierManchester Metropolitan University
Rittweger, Jörnjoern.rittweger@dlr.de
Niebauer, JosefUniversity of Salzburg
Mueller, ErichUniversity of Salzburg
Narici, MarcoManchester Metropolitan University
Datum:2011
Erschienen in:Scandinavian Journal of Medicine & Science in Sports
Referierte Publikation:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:23
Seitenbereich:Seiten 29-38
Status:veröffentlicht
Stichwörter:muscle, human, eccentric, extracellular matrix, focal adhesion, costamere, tenascin-C, focal adhesion kinase
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Jörn Rittweger
Hinterlegt am:09 Sep 2011 09:16
Letzte Änderung:12 Dez 2013 21:20

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