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Variation in the determinants of power of chemically skinned type I rat soleus muscle fibres

Gilliver, Sally F and Jones, David A and Rittweger, Jörn and Degens, Hans (2011) Variation in the determinants of power of chemically skinned type I rat soleus muscle fibres. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 197, pp. 311-319. ISSN 0340-7594.

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Abstract

We explored to which extent maximal velocity of shortening (Vmax), force per cross-sectional area (specific tension, Po) and curvature of the force–velocity relationship (a/Po in the Hill equation) contribute to differences in peak power of single, chemically skinned rat type I fibres. Force–velocity relationships were determined from isotonic contractions of 94 maximally activated fibres. Peak power (±SD) was 3.50 ± 1.64 W L-1. There was a tenfold range of peak power and five-, six- and fourfold ranges for Po, Vmax and a/Po, respectively. None of the differences between fibres was explicable by differences in myosin heavy or light chain composition. The inverse relationship between a/Po and Vmax suggests a similar underlying cause. Fitting the data to the Huxley (Progr Biophys Biophys Chem 7:255–318, 1957) crossbridge model showed that the rate constant g2 and the sum of the rate constants (f ? g1) co-varied, both being low in the slowest fibres. Approximately 16% of the variation in Po could be explained by variation in the proportion of attached cycling cross-bridges (f/(f ? g1)), but the origin of most of the variance in Po remains unknown.

Document Type:Article
Title:Variation in the determinants of power of chemically skinned type I rat soleus muscle fibres
Authors:
AuthorsInstitution or Email of Authors
Gilliver, Sally FManchester Metropolitan University
Jones, David AManchester Metropolitan University
Rittweger, Jörnjoern.rittweger@dlr.de
Degens, HansManchester Metropolitan University
Date:2011
Journal or Publication Title:Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Refereed publication:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:197
Page Range:pp. 311-319
ISSN:0340-7594
Status:Published
Keywords:Skeletal muscle � Skinned fibres � Power � Force–velocity relationship
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Jörn Rittweger
Deposited On:16 Jun 2011 12:37
Last Modified:12 Dec 2013 21:16

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