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Bone geometry and volumetric bone mineral density in girls with Turner syndrome of different pubertal stages

Soucek, Ondrej und Lebl, Jan und Snajderova, Marta und Kolouskova, Stanislava und Rocek, Miloslav und Cinek, Ondrej und Rittweger, Jörn und Sumnik, Zdenek (2011) Bone geometry and volumetric bone mineral density in girls with Turner syndrome of different pubertal stages. Clinical Endocrinology, 74, Seiten 445-452.

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Kurzfassung

Objective An increased rate of fractures has been reported in patients with Turner syndrome (TS). We aimed to assess bone geometry and volumetric bone mineral density (vBMD) at the radius in girls with TS and to evaluate the relationships between bone parameters and fracture history. Methods and design Sixty-seven girls with TS aged 6–19 years treated currently or in the past with growth hormone (GH) and/or oestrogens were examined using peripheral quantitative computed tomography. Results were compared to reference data. Results Cortical area and cortical thickness were low in all age groups (all P < 0.001). Height-adjusted total bone area at the diaphysis was increased in prepubertal and postpubertal girls (mean Z-score 1.0, P < 0.05 for both) and normal in the pubertal group (mean Z-score 0.1). Cortical vBMD was decreased (mean age-specific Z-scores )2.0, )1Æ6 and )1.0 for prepubertal, pubertal and postpubertal groups, respectively, P < 0.01 for all groups). Height- , age- and cortical thickness-adjusted cortical vBMD was positively correlated to the duration of GH therapy (P = 0.012) and to oestrogen administration (P = 0.047). Girls with a history of fractures had lower total vBMD at the metaphysis compared to nonfractured TS girls (mean Z-scores )1.7 vs )0.9, P = 0.04). Conclusions There is a cortical bone deficit in girls with TS characterized by low cortical area, thin cortex and probably decreased cortical vBMD. Early commencement of GH therapy, as well as oestrogen replacement, is associated with higher cortical vBMD. Further studies should investigate the potential causality of this relation.

Dokumentart:Zeitschriftenbeitrag
Titel:Bone geometry and volumetric bone mineral density in girls with Turner syndrome of different pubertal stages
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Soucek, OndrejCharles Uninversity Prague
Lebl, JanCharles Uninversity Prague
Snajderova, MartaCharles Uninversity Prague
Kolouskova, StanislavaCharles Uninversity Prague
Rocek, MiloslavCharles Uninversity Prague
Cinek, OndrejCharles Uninversity Prague
Rittweger, Jörnjoern.rittweger@dlr.de
Sumnik, ZdenekCharles Uninversity Prague
Datum:April 2011
Erschienen in:Clinical Endocrinology
Referierte Publikation:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:74
Seitenbereich:Seiten 445-452
Status:veröffentlicht
Stichwörter:Turner syndrome, volumetric bone density, human growth hormone, estrogens
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Jörn Rittweger
Hinterlegt am:27 Jun 2011 09:28
Letzte Änderung:26 Mär 2013 13:27

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