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Effects of oxidation in the power of chemically skinned rat soleus fibres

Gilliver, Sally F und Jones, David A und Rittweger, Jörn und Degens, Hans (2010) Effects of oxidation in the power of chemically skinned rat soleus fibres. Journal of Musculoskeletal and Neuronal Interactions, 10 (4), Seiten 245-248.

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Oxidation alters calcium sensitivity, and decreases maximum isometric force (Po) and shortening velocity (Vmax) of single muscle fibres. To examine the effect of oxidation on the curvature of the force-velocity relationship, which determines muscle power in addition to Po and Vmax, skinned rat type I fibres were maximally activated at 15ºC in a solution with pCa 4.5 and subjected to isotonic contractions before and after 4-min incubation in 50 mM H2O2 (n=10) or normal relaxing solution (n=3). In five oxidised and four control fibres the rate of force redevelopment (ktr), following a rapid release and re-stretch, was measured. This gives a measure of the sum of the rate constants for cross-bridge attachment (f) and detachment (g1): (f+g1). H2O2 reduced Po, Vmax and ktr by 19%, 21% and 24% respectively (P<0.001), while the shape of the force-velocity relationship was unchanged. Fitting data to the Huxley cross-bridge model suggested that oxidation decreased both the rate constant for cross-bridge attachment (f), and detachment of negatively strained cross-bridges (g2), similar to the effect of reduced activation1. This suggests that oxidative modification is a possible cause of the variation in contractile properties between muscle fibres of the same type2.

Titel:Effects of oxidation in the power of chemically skinned rat soleus fibres
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iD
Gilliver, Sally FManchester Metropolitan UniversityNICHT SPEZIFIZIERT
Jones, David AManchester Metropolitan UniversityNICHT SPEZIFIZIERT
Rittweger, Jörnjoern.rittweger@dlr.deNICHT SPEZIFIZIERT
Degens, HansManchester Metropolitan UniversityNICHT SPEZIFIZIERT
Datum:Dezember 2010
Erschienen in:Journal of Musculoskeletal and Neuronal Interactions
Referierte Publikation:Ja
In Open Access:Ja
In ISI Web of Science:Ja
Seitenbereich:Seiten 245-248
Stichwörter:Skeletal Muscle, Skinned Fibres, Power, Force-Velocity Relationship, Oxidation
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Rittweger, Jörn
Hinterlegt am:13 Dez 2010 09:46
Letzte Änderung:04 Apr 2013 16:26

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