elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Contact | Deutsch
Fontsize: [-] Text [+]

Verification of the SWITCH Test for Determination of Cyto- and Genotoxicity by Simulated Space Radiation Qualities.

Zahoor ul Hassan, Ahmed (2010) Verification of the SWITCH Test for Determination of Cyto- and Genotoxicity by Simulated Space Radiation Qualities. Master's, University of Applied Science Bonn-Rhein-Sieg.

Full text not available from this repository.

Abstract

Before humans embark on long term space missions, it is very important to understand hazards posed by space radiations. Radiations above a certain level can lead to death or have long term effects including cancer. This study is based on the bacterial SWITCH test which has the capability to report on genotoxicity as well as cytotoxicity of space quality radiations (as well as on toxicity of chemicals and other agents) and has been developed by the Radiation Biology group at German Aerospace Center (DLR). The test was used in this study to obtain data on genotoxicity and cytotoxicity of different qualities of X-rays as well as of accelerated heavy ions, the latter representing a very important component of space radiation. It was shown that toxicity of radiations varies with its quality. Radiation energy (dose) is only one factor contributing to the genotoxicity and cytotoxicity of radiations, another important factor is the linear energy transfer (LET). Another important outcome was that cytotoxicity and genotoxicity are independent factors and are not correlated. An effort was also done to understand the structure of SWITCH plasmid present in these bacteria by using restriction analysis to analyze SWITCH and its precursor plasmids.

Document Type:Thesis (Master's)
Title:Verification of the SWITCH Test for Determination of Cyto- and Genotoxicity by Simulated Space Radiation Qualities.
Authors:
AuthorsInstitution or Email of Authors
Zahoor ul Hassan, AhmedUNSPECIFIED
Date:2010
Number of Pages:81
Status:Published
Keywords:space radiation, bacterial SWITCH test, genotoxicity, cytotoxicity
Institution:University of Applied Science Bonn-Rhein-Sieg
Department:Department of Natural Sciences
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kerstin Kopp
Deposited On:15 Oct 2010 12:46
Last Modified:15 Oct 2010 12:46

Repository Staff Only: item control page

Browse
Search
Help & Contact
Informationen
electronic library is running on EPrints 3.3.12
Copyright © 2008-2012 German Aerospace Center (DLR). All rights reserved.