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The 2nd Berlin BedRest study: protocol and implementation

Belavy, Daniel and Bock, Oliver and Börst, Hendrikje and Armbrecht, Gabriele and Gast, Ulf and Degner, Corinna and Beller, Gisela and Soll, Henning and Salanova, Michele and Habazettl, Helmut and Heer, Martina and de Haan, Arnold and Stegeman, Dick F and Cerretelli, Paolo and Blottner, Dieter and Rittweger, Jörn and Gelfi, Cecilia and Kornak, Uwe and Felsenberg, Dieter (2010) The 2nd Berlin BedRest study: protocol and implementation. Journal of Musculoskeletal and Neuronal Interactions, 10 (3), pp. 207-219. ISSN 1108-7161.

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Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p<.0001), though similarly in all groups (p≥.17). Body weight changes differed between groups (p<.0001) with decreases in the CTR-group, marginal decreases in the RE-group and the RVEgroup displaying significant decreases in body-weight beyond bed-rest day-51 only. In light of events and experiences of the current study, recommendations on various aspects of bed-rest ethodology are also discussed.

Document Type:Article
Title:The 2nd Berlin BedRest study: protocol and implementation
AuthorsInstitution or Email of Authors
Belavy, DanielCharite - University Medicine Berlin
Bock, OliverCharite - University Medicine Berlin
Börst, HendrikjeCharite - University Medicine Berlin
Armbrecht, GabrieleCharite - University Medicine Berlin
Gast, UlfCharite - University Medicine Berlin
Degner, CorinnaCharite - University Medicine Berlin
Beller, GiselaCharite - University Medicine Berlin
Soll, Henninghenning.soll@dlr.de
Salanova, MicheleCharite - University Medicine Berlin
Habazettl, HelmutCharite - University Medicine Berlin
Heer, MartinaProfil Research
de Haan, ArnoldFree University Amsterdam
Stegeman, Dick FNijmegen University
Cerretelli, PaoloUniversity Milan
Blottner, DieterCharite - University Medicine Berlin
Rittweger, Jörnjoern.rittweger@dlr.de
Gelfi, CeciliaUniversity Milan
Kornak, UweCharite - University Medicine Berlin
Felsenberg, DieterCharite - University Medicine Berlin
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
In Open Access:Yes
In ISI Web of Science:Yes
Page Range:pp. 207-219
Keywords:Spaceflight, Microgravity, Countermeasures, Inactivity, Exercise
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Jörn Rittweger
Deposited On:11 Oct 2010 09:25
Last Modified:26 Mar 2013 13:20

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