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Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation

Moriggi, Manuela und Vasso, Michele und Fania, Chiara und Capitanio, Daniele und Bonifacio, Gaetano und Salanova, Michele und Blottner, Dieter und Rittweger, Jörn und Felsenberg, Dieter und Cerretelli, Paolo und Gelfi, Cecilia (2010) Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation. Proteomics, 10, Seiten 3756-3774.

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The present investigation, the first in the field, was aimed at analyzing differentially, on individual samples, the effects of 55 days of horizontal bed rest, a model for microgravity, on myosin heavy and myosin light chain isoforms distribution (by SDS) and on the proteome (by 2-D DIGE and MS) in the vastus lateralis (VL), a mixed type II/I (50:50%) head of the quadriceps and in the calf soleus (SOL), a predominantly slow (35:65%) twitch muscle. Two separate studies were performed on six subjects without (BR) and six with resistive vibration exercise (RVE) countermeasures, respectively. Both VL and SOL underwent in BR decrements of 15% in cross-sectional area and of 22% in maximal torque that were prevented by RVE. Myosin heavy chain distribution showed increased type I and decreased type IIA in BR both in VL and in SOL, the opposite with RVE. A substantial downregulation of proteins involved in aerobic metabolism characterized both in SOL and VL in BR. RVE reversed the pattern more in VL than in SOL, whereas proteins involved in anaerobic glycolysis were upregulated. Proteins from the Z-disk region and from costamers were differently dysregulated during bed rest (both BR and RVE), particularly in VL.

Dokumentart:Zeitschriftenbeitrag
Titel:Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Moriggi, ManuelaUniversity of Milan
Vasso, MicheleUniversity of Milan
Fania, ChiaraUniversity of Milan
Capitanio, DanieleUniversity of Milan
Bonifacio, GaetanoUniversity of Milan
Salanova, MicheleCharité - University Medicine Berlin
Blottner, DieterCharité - University Medicine Berlin
Rittweger, Jörnjoern.rittweger@dlr.de
Felsenberg, DieterCharité - University Medicine Berlin
Cerretelli, PaoloCNR Milan
Gelfi, CeciliaUniversity of Milan
Datum:2010
Erschienen in:Proteomics
Referierte Publikation:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:10
Seitenbereich:Seiten 3756-3774
Status:veröffentlicht
Stichwörter:2-D DIGE / Bed rest / Biomedicine / Exercise countermeasures / Mass Spectrometry / Muscle
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Jörn Rittweger
Hinterlegt am:23 Nov 2010 13:10
Letzte Änderung:12 Dez 2013 21:01

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