Moeller, Ralf and Reitz , Guenther and Douki, Thierry and Cadet, Jean and Horneck, Gerda and Stan-Lotter, Helga (2010) UV photoreactions of the extremely haloalkaliphilic euryarchaeon Natronomonas pharaonis. Fems Microbiology Ecology, 73 (2), pp. 271-277. Federation of European Microbiological Societies, Published by Blackwell Publishing Ltd.. DOI: 10.1111/j.1574-6941.2010.00893.x.
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The objective of this study was to investigate the photobiological responses of the haloalkaliphilic euryarchaeon Natronomonas pharaonis to environmentally relevant polychromatic UV radiation, simulating either the present UV radiation climate (λ>290 nm) or that of the early Earth (λ>220 nm), and to monochromatic UVC radiation (λ=254 nm) for comparison with the literature data. UV-induced bipyrimidine DNA photoproducts were determined using a sensitive and accurate HPLC tandem mass spectrometry assay, allowing to identify and quantify each type of photoproducts formed in the DNA of a UV-irradiated halophilic archaeon. The thymine cytosine (TC) pyrimidine (6-4) pyrimidone photoproduct and the TC cyclobutane pyrimidine dimer accounted for almost 80% of the total induced DNA photolesions, regardless of the wavelength range tested. These prominent formation rates of TC photoproducts correlated with the genomic frequencies of TC dinucleotides in N. pharaonis.
|Title:||UV photoreactions of the extremely haloalkaliphilic euryarchaeon Natronomonas pharaonis|
|Journal or Publication Title:||Fems Microbiology Ecology|
|In ISI Web of Science:||Yes|
|Page Range:||pp. 271-277|
|Publisher:||Federation of European Microbiological Societies, Published by Blackwell Publishing Ltd.|
|Keywords:||halophilic archaea, Natronomonas pharaonis, environmental UV radiation, germicidal UV radiation, DNA photoproducts, photoreaction|
|HGF - Research field:||Aeronautics, Space and Transport (old)|
|HGF - Program:||Space (old)|
|HGF - Program Themes:||W FR - Forschung unter Weltraumbedingungen (old)|
|DLR - Research area:||Space|
|DLR - Program:||W FR - Forschung unter Weltraumbedingungen|
|DLR - Research theme (Project):||W - Vorhaben Strahlenbiologie (old)|
|Institutes and Institutions:||Institute of Aerospace Medicine > Radiation Biology|
|Deposited By:||Kerstin Kopp|
|Deposited On:||01 Sep 2010 11:23|
|Last Modified:||04 Apr 2013 16:22|
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