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Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise

Rittweger, Jörn and Beller, Gisela and Armbrecht, Gabriele and Mulder, Edwin and Buehring, Björn and Gast, Ulf and Dimeo, Fernando and Schubert, Harald and de Haan, Arnold and Stegeman, Dick F. and Schiessl, Hans and Felsenberg, Dieter (2010) Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise. Bone, 46 (1), pp. 137-147.

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Abstract

Bed rest is a recognized model for muscle atrophy and bone loss in space flight and in clinical medicine. We hypothesized that whole body vibration in combination with resistive exercise (RVE) would be an effective countermeasure. Twenty healthy male volunteers underwent horizontal bed rest for 56 days and were randomly assigned either to a group that performed RVE 11 times per week or to a group that underwent bed rest only (Ctrl). Bone mineral content (BMC) was assessed by peripheral quantitative computed tomography (pQCT) in the tibia and the radius and by dual x-ray absorptiometry (DXA) in the hip and lumbar spine at baseline and at regular intervals during bed rest and a 12-month follow-up. RVE appeared to protect muscle size and function, and it also prevented bone loss (p-values between b0.001 and 0.01). Bone losses were largest in the distal tibia epiphysis, where BMC declined from 421.8 mg/mm (SD 51.3) to 406.6 mg/mm (SD 52.7) in Ctrl, but only from 411.1 mg/mm (SD 56.6) to 409.6 mg/mm (SD 66.7) in RVE. Most of the BMC losses were recovered by 12-month follow-up. Analyses showed that the epiphyseal cortex, rather than spongiosa, depicted the most pronounced changes during bed rest and recovery. These results suggest that the combined countermeasure applied in this study is effective to prevent bone losses from the tibia. This underlines the importance of mechanical usage for the maintenance of the human skeleton.

Document Type:Article
Title:Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise
Authors:
AuthorsInstitution or Email of Authors
Rittweger, JörnManchester Metropolitan University
Beller, GiselaCharité Campus Benjamin Franklin
Armbrecht, GabrieleCharité Campus Benjamin Franklin
Mulder, EdwinVrije Universiteit Amsterdam
Buehring, BjörnCharité Campus Benjamin Franklin
Gast, UlfCharité Campus Benjamin Franklin
Dimeo, FernandoCharité Campus Benjamin Franklin
Schubert, HaraldVrije Universiteit Amsterdam
de Haan, ArnoldVrije Universiteit Amsterdam
Stegeman, Dick F.Radbout University Nijmegen
Schiessl, HansNovotec Medical
Felsenberg, DieterCharité Campus Benjamin Franklin
Date:January 2010
Journal or Publication Title:Bone
Refereed publication:Yes
In Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:46
Page Range:pp. 137-147
Status:Published
Keywords:Space flight Microgravity Countermeasure Volumetric bone mineral density Training
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Jörn Rittweger
Deposited On:28 Apr 2010 12:18
Last Modified:12 Dec 2013 20:56

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