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Resistive vibration exercise attenuates bone and muscle atrophy in 56-days of bed-rest: whole body DXA and biochemical markers of bone metabolism

Armbrecht, Gabriele und Belavy, Daniel Ludovic und Gast, Ulf und Bongrazio, Martina und Touby, Frank und Beller, Gise und Roth, H.J. und Perschel, Frank H. und Rittweger, Jörn und Felsenberg, Dieter (2010) Resistive vibration exercise attenuates bone and muscle atrophy in 56-days of bed-rest: whole body DXA and biochemical markers of bone metabolism. Osteoporosis International, 21 (4), Seiten 597-607.

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Kurzfassung

Summary During and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whilst increasing bone formation. Introduction To investigate the effectiveness of a resistive vibration exercise (RVE) countermeasure during prolonged bed rest using serum markers of bone metabolism and whole-body dual X-ray absorptiometry (DXA) as endpoints. Methods Twenty healthy male subjects underwent 8 weeks of bed rest with 12 months follow-up. Ten subjects performed RVE. Blood drawings and DXA measures were conducted regularly during and after bed rest. Results Bone resorption increased in the CTRL group with a less severe increase in the RVE group (p = 0.0004). Bone formation markers increased in the RVE group but decreased marginally in the CTRL group (p < 0.0001). At the end of bed rest, the CTRL group showed significant loss in leg bone mass (−1.8(0.9)%, p = 0.042) whereas the RVE group did not (−0.7(0.8)%, p = 0.405) although the difference between the groups was not significant (p = 0.12). Conclusions The results suggest the countermeasure restricts increases in bone resorption, increased bone formation, and reduced bone loss during bed rest.

Dokumentart:Zeitschriftenbeitrag
Titel:Resistive vibration exercise attenuates bone and muscle atrophy in 56-days of bed-rest: whole body DXA and biochemical markers of bone metabolism
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Armbrecht, GabrieleCharité Campus Benjamin Franklin
Belavy, Daniel LudovicCharité Campus Benjamin Franklin
Gast, UlfCharité Campus Benjamin Franklin
Bongrazio, MartinaCharité Campus Benjamin Franklin
Touby, FrankCharité Campus Benjamin Franklin
Beller, GiseCharité Campus Benjamin Franklin
Roth, H.J.Labor Limbach
Perschel, Frank H.Charité Campus Benjamin Franklin
Rittweger, JörnManchester Metropolitan University
Felsenberg, DieterCharité Campus Benjamin Franklin
Datum:April 2010
Erschienen in:Osteoporosis International
Referierte Publikation:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:21
Seitenbereich:Seiten 597-607
Status:veröffentlicht
Stichwörter:Bone turnover markers - DXA - Microgravity - Re-ambulation - Vibration exercise
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Jörn Rittweger
Hinterlegt am:28 Apr 2010 12:20
Letzte Änderung:04 Apr 2013 16:21

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