Toxicity of combustion condensates on human cells
Stojičić, Nevena (2009) Toxicity of combustion condensates on human cells. Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.
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Combustion exhausts emitted from traffic and industry sources represent the main contributors to air pollution in urban areas, and as such they have been associated with increased mortality and cardiorespiratory morbidity. Despite intense research, the mechanism of these correlations is still not fully understood. Most of the studies published so far have focused their research on only soot particles or their surrogates (e.g. carbon black), thereby neglecting other combustion by-products present in exhausts. The “cool trap” method, applied in this work, collects particulate and gaseous components of the combustion exhaust. Utilisation of such heterogeneous mixtures can give a better insight in the toxicity of combustion exhausts. The main aim of this work was to study the toxicity of combustion condensates on human alveolar (A-549) and human monocyte-like (U-937) cell lines. The combustion condensates originated from premixed ethylene/oxygen laboratory flames or from diesel fuel combustion. Pre-screening of toxicity was performed by using bacterial SWITCH test which utilises the recombinant S. typhimurium TA1535 pSWITCH strain.
|Document Type:||Thesis (Dissertation)|
|Title:||Toxicity of combustion condensates on human cells|
|Number of Pages:||151|
|Keywords:||Human cells, Toxicity of combustion condensates, Air pollution, Health impacts|
|Institution:||Rheinische Friedrich-Wilhelms-Universität Bonn|
|HGF - Research field:||Aeronautics, Space and Transport|
|HGF - Program:||Space|
|HGF - Program Themes:||W FR - Forschung unter Weltraumbedingungen|
|DLR - Research area:||Space|
|DLR - Program:||W FR - Forschung unter Weltraumbedingungen|
|DLR - Research theme (Project):||W - Vorhaben Strahlenbiologie (old)|
|Institutes and Institutions:||Institute of Aerospace Medicine > Radiation Biology|
|Deposited By:||Kerstin Kopp|
|Deposited On:||12 Apr 2010 13:31|
|Last Modified:||12 Apr 2010 13:31|
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