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Determinants of bone loss during immobilization

Rittweger, Jörn (2009) Determinants of bone loss during immobilization. LN-MCP, Institut za patolosko fiziologijo, Medicinska fakulteta, Univerza v Ljubljani. Federation of the European Physiological Societies 2009, 12.-15.11.2009, Ljubljana, Slovenien. ISBN 978-961-91250-5-2

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Bone losses occur in clinical cases of immobilization, such as stroke and spinal cord injury. In those cases, the rate of bone loss is initially high and levels off after 2-5 years. Experimental bed rest, which is often used as a model of deconditioning effects, is also associated with bone losses from the legs, but not from the arms. Similar effects can be elicited by unilateral lower limb suspension, which disfavours the hypothesis that increased venous pressure can prevent immobilization-induced bone loss. Adequate resistive exercise, conversely, has the potential to act as a countermeasure against bone losses. Data suggest that resistive exercise may be more effective when combined with whole body vibration. There seems to be a wide variation in the time course of bone losses from immobilized limbs, but probably not in the amount of bone losses. The question arises as to what determines this biological variation. Recent data show that bone structure can partly explain different rates of bone loss. Moreover, there is a possibility that the kidney’s ability of calcium excretion is a limiting factor and might hamper immobilization-induced bone losses.

Dokumentart:Konferenzbeitrag (Vortrag)
Titel:Determinants of bone loss during immobilization
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID
Rittweger, Jörnjoern.rittweger@dlr.deNICHT SPEZIFIZIERT
Datum:November 2009
In Open Access:Nein
In ISI Web of Science:Nein
Seitenbereich:Seite 151
Verlag:LN-MCP, Institut za patolosko fiziologijo, Medicinska fakulteta, Univerza v Ljubljani
Stichwörter:Immobilisation, Osteoporose, Knochenabbau, Physiotherapie
Veranstaltungstitel:Federation of the European Physiological Societies 2009
Veranstaltungsort:Ljubljana, Slovenien
Veranstaltungsart:internationale Konferenz
Veranstalter :Federation of the European Physiological Societies
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Beschleunigungsinduzierte Effekte (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Rittweger, Jörn
Hinterlegt am:01 Dez 2009 14:12
Letzte Änderung:01 Dez 2009 14:12

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