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Roles of PprA, IrrE, and RecA in the resistance of Deinococcus radiodurans to germicidal and environmentally relevant UV radiation

Bauermeister, Anja and Bentchikou, Esma and Moeller, Ralf and Rettberg, Petra (2009) Roles of PprA, IrrE, and RecA in the resistance of Deinococcus radiodurans to germicidal and environmentally relevant UV radiation. Archives of Microbiology, 191, pp. 913-918. Springer Berlin / Heidelberg. DOI: 10.1007/s00203-009-0522-7. ISSN 0302-8933 (Print) 1432-072X (Online).

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Abstract

To study the role of different DNA repair genes in the resistance of Deinococcus radiodurans to mono- and polychromatic UV radiation, wild-type strain and knockout mutants in RecA, PprA, and IrrE of D. radiodurans were irradiated with UV-C (254 nm), UV-(A + B) (280–400 nm) and UV-A (315–400 nm) radiation, and survival was monitored. The strain deficient in recA was highly sensitive to UV-C radiation compared to the wild-type, but showed no loss of resistance against irradiation with UV-(A + B) and UV-A, while pprA and irrE-deficient strains exhibited elevated sensitivity to UV-A and UV-(A + B) radiation. These results suggest that the repair of DNA double-strand breaks is essential after treatment with highly energetic UV-C radiation, whereas protection from oxidative stress may play a greater role in resistance to environmentally relevant UV radiation.

Document Type:Article
Title:Roles of PprA, IrrE, and RecA in the resistance of Deinococcus radiodurans to germicidal and environmentally relevant UV radiation
Authors:
AuthorsInstitution or Email of Authors
Bauermeister, Anja UNSPECIFIED
Bentchikou, Esma Institut de Génétique et Microbiologie, Université Paris-Sud 11, CNRS UMR8621, CEA LRC 42 V, Bâtiment 409, 91405, Orsay, France
Moeller, Ralf UNSPECIFIED
Rettberg, Petra UNSPECIFIED
Date:2009
Journal or Publication Title:Archives of Microbiology
Refereed publication:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:191
DOI:10.1007/s00203-009-0522-7
Page Range:pp. 913-918
Publisher:Springer Berlin / Heidelberg
ISSN:0302-8933 (Print) 1432-072X (Online)
Status:Published
Keywords:Deinococcus radiodurans, 254 nm UV-C, Environmental UV radiation, DNA repair
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kerstin Kopp
Deposited On:01 Dec 2009 14:15
Last Modified:26 Mar 2013 13:12

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