Bauermeister, Anja and Bentchikou, Esma and Moeller, Ralf and Rettberg, Petra (2009) Roles of PprA, IrrE, and RecA in the resistance of Deinococcus radiodurans to germicidal and environmentally relevant UV radiation. Archives of Microbiology, 191, pp. 913-918. Springer Berlin / Heidelberg. DOI: 10.1007/s00203-009-0522-7. ISSN 0302-8933 (Print) 1432-072X (Online).
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To study the role of different DNA repair genes in the resistance of Deinococcus radiodurans to mono- and polychromatic UV radiation, wild-type strain and knockout mutants in RecA, PprA, and IrrE of D. radiodurans were irradiated with UV-C (254 nm), UV-(A + B) (280–400 nm) and UV-A (315–400 nm) radiation, and survival was monitored. The strain deficient in recA was highly sensitive to UV-C radiation compared to the wild-type, but showed no loss of resistance against irradiation with UV-(A + B) and UV-A, while pprA and irrE-deficient strains exhibited elevated sensitivity to UV-A and UV-(A + B) radiation. These results suggest that the repair of DNA double-strand breaks is essential after treatment with highly energetic UV-C radiation, whereas protection from oxidative stress may play a greater role in resistance to environmentally relevant UV radiation.
|Title:||Roles of PprA, IrrE, and RecA in the resistance of Deinococcus radiodurans to germicidal and environmentally relevant UV radiation|
|Journal or Publication Title:||Archives of Microbiology|
|In ISI Web of Science:||Yes|
|Page Range:||pp. 913-918|
|Publisher:||Springer Berlin / Heidelberg|
|ISSN:||0302-8933 (Print) 1432-072X (Online)|
|Keywords:||Deinococcus radiodurans, 254 nm UV-C, Environmental UV radiation, DNA repair|
|HGF - Research field:||Aeronautics, Space and Transport (old)|
|HGF - Program:||Space (old)|
|HGF - Program Themes:||W FR - Forschung unter Weltraumbedingungen (old)|
|DLR - Research area:||Space|
|DLR - Program:||W FR - Forschung unter Weltraumbedingungen|
|DLR - Research theme (Project):||W - Vorhaben Strahlenbiologie (old)|
|Institutes and Institutions:||Institute of Aerospace Medicine > Radiation Biology|
|Deposited By:||Kerstin Kopp|
|Deposited On:||01 Dec 2009 14:15|
|Last Modified:||26 Mar 2013 13:12|
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