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High salt intake as an additional risk factor for protein losses in head down tilt bed rest

Buehlmeier, Judith and Frings-Meuthen, Petra and Baecker, Natalie and Stehle, Peter and Heer, Martina (2009) High salt intake as an additional risk factor for protein losses in head down tilt bed rest. In: Abstractband. 17th IAA Humans in Space Symposium, Moskau, Russland.

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Abstract

Human spaceflight is associated with a loss of body protein. Additionally astronauts tend towards a high intake of sodium chloride (NaCl), which has recently been shown to induce low grade metabolic acidosis. In several patterns, e.g. chronical renal failure, metabolic acidosis is associated with protein catabolism. We therefore hypothesized that high dietary intake of NaCl enforces protein losses in head down tilt bed rest (HDBR). Eight healthy male subjects participated in a 14-day bed rest study in the metabolic ward of the DLR – Institute of Aerospace Medicine, Cologne, Germany. The study was carried out in a cross over design, consisting of two phases. The diet was identical in both study phases with the exception of NaCl-intake: Every subject received a low NaCl diet in one phase and a high in another one. Plasma pH did not change significantly (p=0.061), but plasma bicarbonate and base excess decreased (both p<0.001) with high NaCl intake in HDBR. Nitrogen balance in HDBR was negative, as expected in immobilization with low NaCl diet ( 0.47 ± 2.3 g/d). However, high NaCl intake in HDBR exacerbated the negative nitrogen balance to 1.26 ± 2.3 g/d (p<0.001). We conclude that high NaCl intake induces low grade metabolic acidosis during HDBR. Low grade metabolic acidosis may be a reason for an increased protein turnover reflected by an exaggerated negative nitrogen balance in HDBR. Accordingly, a high NaCl intake may exacerbate loss of body protein in µG.

Document Type:Conference or Workshop Item (Speech)
Title:High salt intake as an additional risk factor for protein losses in head down tilt bed rest
Authors:
AuthorsInstitution or Email of Authors
Buehlmeier, JudithUNSPECIFIED
Frings-Meuthen, PetraUNSPECIFIED
Baecker, NatalieUNSPECIFIED
Stehle, PeterIEL, Universität Bonn
Heer, MartinaUNSPECIFIED
Date:June 2009
Journal or Publication Title:Abstractband
Keywords:acid base balance, nitrogen balance, sodium chloride, space flight analogue
Event Title:17th IAA Humans in Space Symposium
Event Location:Moskau, Russland
Event Type:international Conference
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Judith Bühlmeier
Deposited On:05 Nov 2009 13:24
Last Modified:05 Nov 2009 13:24

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