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Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization

Liphardt, Anna-Maria und Mündermann, Annegret und Koo, Seungbum und Bäcker, Natalie und Andriacchi, Thomas P. und Zange, Jochen und Mester, Joachim und Heer, Martina (2009) Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization. Osteoarthritis and Cartilage. Elsevier. ISSN 1063-4584. (im Druck)

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Kurzfassung

OBJECTIVE: To test the hypotheses that 1) 14-days of immobilization of young healthy subjects using a 6 degrees -"head-down-tilt-bed-rest"-model (6 degrees -HDT) would reduce cartilage thickness in the knee and serum Cartilage oligometric matrix protein (COMP) concentration and 2) isolated whole body vibration training would counteract the bed rest effects. METHOD: The study was performed and designed in compliance with the Declaration of Helsinki and is registered as trial DRKS00000140 in the German Clinical Trial Register (register.germanctr.de). Eight male healthy subjects (78.0+/-9.5kg; 179+/-0.96cm, 26+/-5 years) performed 14 days of 6 degrees -HDT. The study was designed as a cross-over-design with two study phases: a training and a control intervention. During the training intervention, subjects underwent 2x5-min whole body vibration training/day (Frequency: 20Hz; amplitude: 2-4mm). Magnetic resonance (MR) images (slice thickness: 2mm; in-plane resolution: 0.35x0.35mm; pixels: 448x512) were taken before and after the 6 degrees -HDT periods. Average cartilage thicknesses were calculated for the load bearing regions on the medial and lateral articulating surfaces in the femur and tibia. RESULTS: While the control intervention resulted in an overall loss in average cartilage thickness of -8% (pre: 3.08mm+/-0.6mm post: 2.82mm+/-0.6mm) in the weight-bearing regions of the tibia, average cartilage thickness increased by 21.9% (pre: 2.66mm+/-0.45mm post: 3.24mm+/-0.63mm) with the vibration intervention. No significant differences were found in the weight-bearing regions of the femur. During both interventions, reduced serum COMP concentrations were observed (control intervention: -13.6+/-8.4%; vibration intervention: -9.9+/-3.3%). CONCLUSION: The results of this study suggest that articular cartilage thickness is sensitive to unloading and that vibration training may be a potent countermeasure against these effects. The sensitivity of cartilage to physical training is of high relevance for training methods in space flight, elite and sport and rehabilitation after illness or injury

Dokumentart:Zeitschriftenbeitrag
Titel:Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization
Autoren:
AutorenInstitution oder E-Mail-Adresse der Autoren
Liphardt, Anna-MariaNICHT SPEZIFIZIERT
Mündermann, AnnegretStanford University, Stanford, CA, USA
Koo, SeungbumChung-Ang University, Seoul, South Korea
Bäcker, NatalieNICHT SPEZIFIZIERT
Andriacchi, Thomas P.Stanford University, Stanford, CA, USA
Zange, JochenNICHT SPEZIFIZIERT
Mester, JoachimDeutsche Sporthochschule Köln
Heer, MartinaNICHT SPEZIFIZIERT
Datum:2009
Erschienen in:Osteoarthritis and Cartilage
Referierte Publikation:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Verlag:Elsevier
ISSN:1063-4584
Status:im Druck
Stichwörter:Aerospace; Aerospace Medicine; Articular; Bed Rest; Cartilage; COMP; Compliance; countermeasure; deutsch; Femur; Germany; HDT; Immobilization; Injuries; Knee; Magnetic resonance; Male; Methods; Protein; rehabilitation; Rest; space; Space Flight; Tibia; Training; Unloading; Vibration; Weight-Bearing
HGF - Forschungsbereich:Verkehr und Weltraum (alt)
HGF - Programm:Weltraum (alt)
HGF - Programmthema:W FR - Forschung unter Weltraumbedingungen (alt)
DLR - Schwerpunkt:Weltraum
DLR - Forschungsgebiet:W FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):W - Vorhaben Beschleunigungsinduzierte Effekte (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Dr.rer.nat. Jochen Zange
Hinterlegt am:05 Nov 2009 13:37
Letzte Änderung:26 Feb 2013 15:04

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