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HIGH-LET ION BEAMS ACTIVATE THE TRANSCRIPTION FACTOR NF-κB IN HUMAN CELLS

Hellweg, Christine E. and Baumstark-Khan, Christa and Spitta, Luis F. and Ruscher, R. and Arenz, Andrea and Lau, Patrick and Meier, Matthias M. and Testard, I. and Reitz, Günther (2007) HIGH-LET ION BEAMS ACTIVATE THE TRANSCRIPTION FACTOR NF-κB IN HUMAN CELLS. In: Fachverband für Strahlenschutz, Ion Beams in Biology and Medicine Fortschritte im Strahlenschutz. TÜV Media GmbH, TÜV Rheinland Group. pp. 171-172. ISBN 978-3-8249-1071-7. ISSN 1013-4506

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Abstract

Assessment of health risks for astronauts exposed to cosmic radiation during long-term space missions remains an open question. Knowledge of the cellular response to space radiation components can reduce the uncertainty. Apoptosis plays a major role in cancer induction and in acute responses to high radiation doses. In this work, the involvement of the transcription factor Nuclear Factor κB (NF-κB), which can be antiapoptotic, in the response to high LET ion beams was examined by means of a recombinant reporter cell line. Accelerated argon ions (95 MeV/A, LET 232 keV/μm) activate NF-κB dependent gene expression already at low fluences. This could favor the survival of cells with damaged DNA.

Document Type:Book Section
Title:HIGH-LET ION BEAMS ACTIVATE THE TRANSCRIPTION FACTOR NF-κB IN HUMAN CELLS
Authors:
AuthorsInstitution or Email of Authors
Hellweg, Christine E.UNSPECIFIED
Baumstark-Khan, ChristaUNSPECIFIED
Spitta, Luis F.UNSPECIFIED
Ruscher, R.UNSPECIFIED
Arenz, AndreaUNSPECIFIED
Lau, PatrickUNSPECIFIED
Meier, Matthias M.UNSPECIFIED
Testard, I.Laboratoire d'Accueil en Radiobiologie avec les Ions Accélérés (LARIA), CIRIL – GANIL, Caen, France
Reitz, GüntherUNSPECIFIED
Date:2007
Journal or Publication Title:Fachverband für Strahlenschutz, Ion Beams in Biology and Medicine
Page Range:pp. 171-172
Editors:
EditorsEmail
Debus, J.UNSPECIFIED
Henrichs, K.UNSPECIFIED
Kraft, G.UNSPECIFIED
Publisher:TÜV Media GmbH, TÜV Rheinland Group
Series Name:Fortschritte im Strahlenschutz
ISSN:1013-4506
ISBN:978-3-8249-1071-7
Status:Published
Keywords:ION BEAMS, cosmic radiation, cancer induction, NF-κB
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kerstin Kopp
Deposited On:25 Feb 2008
Last Modified:27 Apr 2009 14:47

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