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Moeller, Ralf und Stackebrandt, Erko und Douki, Thierry und Cadet, Jean und Rettberg, Petra und Mollenkopf, Hans-Joachim und Reitz, Günther und Horneck, Gerda (2007) DNA bipyrimidine photoproduct repair and transcriptional response of UV-C irradiated Bacillus subtilis. Archives of Microbiology, 188 (4), Seiten 421-431. Springer. doi: 10.1007/s00203-007-0263-4.
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Kurzfassung
Vegetative wild-type and DNA repair-deficient (homologous recombination, recA and nucleotide excision repair, uvrB) Bacillus subtilis cells were exposed to UV-C radiation. Colony formation, DNA bipyrimidine photoproducts and gene expression were measured during cell recovery. Gene expression was measured after 60 min cell recovery where 50% (wild-type), 30% (recA) and 8% (uvrB), respectively, of the UV-C induced DNA photoproducts were repaired. We examined changes in the gene expression following UV exposure in wild-type and both repair-deficient strains. A set of known and unknown genes were found to be significantly up-regulated in wild-type B. subtilis cells, whereas no or lower gene induction was determined for both mutant strains. In addition, the possible roles of newly identified UV-responsive genes are discussed with respect to cellular recovery following exposure to UV irradiation.
| elib-URL des Eintrags: | https://elib.dlr.de/52964/ | ||||||||||||||||||||||||||||||||||||
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| Dokumentart: | Zeitschriftenbeitrag | ||||||||||||||||||||||||||||||||||||
| Titel: | DNA bipyrimidine photoproduct repair and transcriptional response of UV-C irradiated Bacillus subtilis | ||||||||||||||||||||||||||||||||||||
| Autoren: |
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| Datum: | 2007 | ||||||||||||||||||||||||||||||||||||
| Erschienen in: | Archives of Microbiology | ||||||||||||||||||||||||||||||||||||
| Referierte Publikation: | Ja | ||||||||||||||||||||||||||||||||||||
| Open Access: | Nein | ||||||||||||||||||||||||||||||||||||
| Gold Open Access: | Nein | ||||||||||||||||||||||||||||||||||||
| In SCOPUS: | Nein | ||||||||||||||||||||||||||||||||||||
| In ISI Web of Science: | Ja | ||||||||||||||||||||||||||||||||||||
| Band: | 188 | ||||||||||||||||||||||||||||||||||||
| DOI: | 10.1007/s00203-007-0263-4 | ||||||||||||||||||||||||||||||||||||
| Seitenbereich: | Seiten 421-431 | ||||||||||||||||||||||||||||||||||||
| Verlag: | Springer | ||||||||||||||||||||||||||||||||||||
| Status: | veröffentlicht | ||||||||||||||||||||||||||||||||||||
| Stichwörter: | Bacillus subtilis, UV-C radiation, DNA repair, Gene expression, DNA photoproducts | ||||||||||||||||||||||||||||||||||||
| HGF - Forschungsbereich: | Verkehr und Weltraum (alt) | ||||||||||||||||||||||||||||||||||||
| HGF - Programm: | Weltraum (alt) | ||||||||||||||||||||||||||||||||||||
| HGF - Programmthema: | W FR - Forschung unter Weltraumbedingungen (alt) | ||||||||||||||||||||||||||||||||||||
| DLR - Schwerpunkt: | Weltraum | ||||||||||||||||||||||||||||||||||||
| DLR - Forschungsgebiet: | W FR - Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||||||||||||||
| DLR - Teilgebiet (Projekt, Vorhaben): | W - Vorhaben Strahlenbiologie (alt) | ||||||||||||||||||||||||||||||||||||
| Standort: | Köln-Porz | ||||||||||||||||||||||||||||||||||||
| Institute & Einrichtungen: | Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie | ||||||||||||||||||||||||||||||||||||
| Hinterlegt von: | Kopp, Kerstin | ||||||||||||||||||||||||||||||||||||
| Hinterlegt am: | 21 Jan 2008 | ||||||||||||||||||||||||||||||||||||
| Letzte Änderung: | 27 Apr 2009 14:40 |
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