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Treatment of glycogenosis type V (McArdle disease) with creatine and ketogenic diet with clinical scores and with <sup>31</sup>P-MRS on working leg muscle

Vorgerd, Matthias and Zange, Jochen (2007) Treatment of glycogenosis type V (McArdle disease) with creatine and ketogenic diet with clinical scores and with <sup>31</sup>P-MRS on working leg muscle. Acta Mycologica, 26, pp. 59-61. Gaetano Conte Academy. ISSN 1128-2460. (In Press)

Full text not available from this repository.

Abstract

McArdle’s disease is caused by genetic defects of the musclespecific isozyme of glycogen phosphorylase, which block ATP formation from glycogen in skeletal muscle. Creatine supplementation and ketogenic diet have been tested as potential supplements for muscle energy metabolism which may improve muscle symptomatic. Outcome measures were clinical scores describing muscle symptomatic and parameters derived from <sup>31</sup>P-MRS examinations on working muscle. In two placebo controlled cross-over studies low dose creatine showed benefi cial effects on muscle symptoms and performance whereas high dose creatine distinctly worsened muscle symptomatic in patients. In both studies, however, the absence of an elevation in phosphocreatine indicated the absence of a creatine uptake by the muscle fibre. The effects of creatine on muscle symptomatic may be independent from energy metabolism in muscle. In a case study, ketogenic diet improved muscle symptomatic and performance. However, these effects again did not result in <sup>31</sup>P-MRS visible changes in muscle energy metabolism.

Document Type:Article
Title:Treatment of glycogenosis type V (McArdle disease) with creatine and ketogenic diet with clinical scores and with <sup>31</sup>P-MRS on working leg muscle
Authors:
AuthorsInstitution or Email of Authors
Vorgerd, MatthiasRuhr-Universtiät Bochum
Zange, JochenUNSPECIFIED
Date:2007
Journal or Publication Title:Acta Mycologica
Refereed publication:Yes
In ISI Web of Science:Yes
Volume:26
Page Range:pp. 59-61
Editors:
EditorsEmail
Nigro, G.UNSPECIFIED
Publisher:Gaetano Conte Academy
ISSN:1128-2460
Status:In Press
Keywords:McArdle disease; creatine supplementation; ketogenic diet; muscle metabolism; muscle weakness, muscle disease, therapy
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W - no assignement
DLR - Research area:Space
DLR - Program:W - no assignement
DLR - Research theme (Project):W -- no assignement (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Dr.rer.nat. Jochen Zange
Deposited On:17 Aug 2007
Last Modified:27 Apr 2009 14:07

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