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Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebocontrolled, double-blind <sup>31</sup>P-MRS crossover study

Kornblum, Cornelia and Schröder, Rolf and Müller, Klaus and Vorgerd, Matthias and Eggers, J. and Bogdanow, M. and Papassotiropoulos, A. and Fabian, K. and Klockgether, Thomas and Zange, Jochen (2005) Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebocontrolled, double-blind <sup>31</sup>P-MRS crossover study. European Journal of Neurology, 12, pp. 300-309.

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Abstract

The purpose of our randomized, double-blind, placebo-controlled crossover study in 15 patients with chronic progressive external ophthalmoplegia (CPEO) or Kearns–Sayre syndrome (KSS) because of single large-scale mitochondrial (mt) DNA deletions was to determine whether oral creatine (Cr) monohydrate can improve skeletal muscle energy metabolism in vivo. Each treatment phase with Cr in a dosage of 150 mg/kg body weight/day or placebo lasted 6 weeks. The effect of Cr was estimated by phosphorus-31 magnetic resonance spectroscopy (<sup>31</sup>P-MRS), clinical and laboratory tests. <sup>31</sup>P-MRS analysis prior to treatment showed clear evidence of severe mitochondrial dysfunction. However, there were no relevant changes in 31P-MRS parameters under Cr. In particular, phosphocreatine (PCr)/ATP at rest did not increase, and there was no facilitation of post-exercise PCr recovery. Clinical scores and laboratory tests did not alter significantly under Cr, which was tolerated without major side-effects in all patients. Cr supplementation did not improve skeletal muscle oxidative phosphorylation in our series of patients. However, one explanation for our negative findings may be the short study duration or the limited number of patients included.

Document Type:Article
Title:Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebocontrolled, double-blind <sup>31</sup>P-MRS crossover study
Authors:
AuthorsInstitution or Email of Authors
Kornblum, CorneliaUniversität Bonn
Schröder, RolfUniversität Bonn
Müller, KlausUNSPECIFIED
Vorgerd, MatthiasUniversität Bochum
Eggers, J.Universität Bonn
Bogdanow, M.Universität Bonn
Papassotiropoulos, A.Universität Zürich
Fabian, K.Universität Dresden
Klockgether, ThomasUniversität Bonn
Zange, JochenUNSPECIFIED
Date:2005
Journal or Publication Title:European Journal of Neurology
Refereed publication:Yes
In ISI Web of Science:Yes
Volume:12
Page Range:pp. 300-309
Status:Published
Keywords:chronic progressive external ophthalmoplegia, creatine monohydrate, Kearns–Sayre syndrome, mitochondrial disorders, mtDNA deletion, 31P-MRS
HGF - Research field:Aeronautics, Space and Transport (old)
HGF - Program:Space (old)
HGF - Program Themes:W FR - Forschung unter Weltraumbedingungen (old)
DLR - Research area:Space
DLR - Program:W FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):W -- no assignement (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Dr.rer.nat. Jochen Zange
Deposited On:10 Jan 2006
Last Modified:27 Apr 2009 04:45

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